935475-82-4Relevant academic research and scientific papers
Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues
Bjornstal, Olaf T.,Du, Liqin,Jemal, Mauricio A.,Kerwin, Sean M.,Lee, Dallas,Rodebaugh, Mary,Schwartz, Zachary T.,Shelton, Spencer D.,Theisen, Peter D.,Zhao, Zhenze
, (2022/03/23)
Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism. Embarking upon a program to systematically examine potentially more metabolically stable replacements for the catechol rings in rooperol, we report here a general, scalable synthesis of rooperol and analogues that builds on our previous synthetic approach incorporating a key Pd-catalyzed decarboxylative coupling strategy. Using this approach, we have prepared and evaluated the cancer cell cytotoxicity of rooperol and a series of analogues. While none of the analogues examined here were superior to rooperol in preventing the growth of cancer cells, analogues containing phenol or methylenedioxyphenyl replacements for one or both catechol rings were nearly as effective as rooperol.
Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: Synthesis of 2-arylindoles
Ponpandian, Thanasekaran,Muthusubramanian, Shanmugam
supporting information; experimental part, p. 4248 - 4252 (2012/08/28)
The efficient synthesis of 2-arylindoles and 6H-isoindolo[2,1-a]indol-6-one through copper catalysed domino sp-sp2 decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo[1,2-c]quinazolin-6(5H)-one can be obtained with the elimination of trifluoromethyl anion.
