93548-30-2Relevant academic research and scientific papers
Nucleophilic cleavage of acetals using organometallic reagents
Mori, Atsunori,Fujiwara, Junya,Maruoka, Keiji,Yamamoto, Hisashi
, p. 83 - 94 (2007/10/02)
A highly chemo- and stereo-selective cleavage of acetals derived from (-)(2R,4R)-2,4-pentanediol with organoaluminum and organotitanium reagents has been demonstrated. The reactions proceed under mild conditions with excellent yields and high chemoselectivities to give, after removal of the auxiliary, chiral alcohols of high enantiomeric purities.
ASYMMETRIC SYNTHESIS via CHIRAL ACETAL TEMPLATES. 8. REACTIONS WITH ORGANOMETALLIC REAGENTS
Lindell, Stephen D.,Elliott, John D.,Johnson, William S.
, p. 3947 - 3950 (2007/10/02)
The titanium tetrachloride catalyzed coupling of organometallic reagents with chiral acetals 1 is shown to provide a convenient route for the preparation of a variety of chiral alcohols 4 of high optical purity.
NUCLEOPHILIC CLEAVAGES OF ACETALS USING ORGANOTITANIUM REAGENTS. A NEW SYNTHESIS OF CHIRAL ALCOHOLS
Mori, Atsunori,Maruoka, Keiji,Yamamoto, Hisashi
, p. 4421 - 4424 (2007/10/02)
A highly chemo- and stereoselective cleavage of acetals derived from (-)-(2R, 4R)-2,4-pentanediol with organotitanium reagents has been demonstrated.The reraction proceeds under mild condations in excellent yield and high chemoselectivity to give, after removel of auxiliary, the chiral alcohols of high enantiopurities.In addition, complexation of chiral acetals and TiCl4 followed by treatment with n-butyllithium also results in formation of the corresponding n-butylated alcohols with high stereoselectivity.
