93548-89-1

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General Description

1H-Indole-3-carboxylic acid, 1-[(4-chlorophenyl)methyl]- is a chemical compound with a molecular formula C17H13ClN2O2. It is a derivative of indole and is commonly used in organic synthesis and pharmaceutical research. 1H-Indole-3-carboxylic acid, 1-[(4-chlorophenyl)methyl]- has been studied for its potential biological and pharmacological activities, including its role as an inhibitor of enzymes such as cyclooxygenase-2. It has also been investigated for its potential use in the treatment of various diseases and conditions, such as cancer and inflammation. Additionally, it has shown promise as a precursor in the development of new drugs and materials. Overall, 1H-Indole-3-carboxylic acid, 1-[(4-chlorophenyl)methyl]- is a versatile compound with diverse applications in the fields of chemistry, biology, and medicine.

Upstream product

• 75629-57-1 oncrasin-1 
• 622-95-7 4-chlorobenzyl bromide 
• 942-24-5 3-methoxycarbonylindole 
• 761402-59-9 methyl [1-[(4-chlorophenyl)methyl]]-1H-indole-3-carboxylate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant academic research and scientific papers

MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS

Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4-dependent condition more specifically, by contacting MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein E, Q, W, Z, R1, R2, R3, and R4 are as defined herein. Pharmaceutical compositions containing such compounds, as well as compounds themselves, are also provided.

Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives

Hypoxia inducible factor-1 (HIF-1) is the key transcription factor of cellular response to hypoxia and plays a critical role in tumor metastasis. We describe here the discovery and a structure-activity relationship study of a series of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives as novel HIF-1 inhibitors. The two most promising compounds 4g and 4h inhibit HIF-1 transcription with IC50 values of 0.62 and 0.55 μM in vitro, respectively, and they exhibit more efficient HIF-1 inhibition in xenograft tumors than YC-1, a potential anticancer drug targeting HIF-1. In addition, they also remarkably prevent the hypoxia-driven migration of SKOV3 cells in vitro and tumor metastasis in vivo. Further investigation of the mechanism revealed that the two inhibitors could decrease HIF-1α and VEGF expression. These results suggest that our newly synthesized HIF-1 inhibitors 4g and 4h are potential therapeutic agents with which to treat tumor metastasis.

Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities

To optimize the antitumor activity of oncrasin-1, a small molecule RNA polymerase II inhibitor, we evaluated 69 oncrasin-1 analogues for their cytotoxic activity against normal human epithelial cells and K-Ras mutant tumor cells. About 40 of those compoun

Potential antitumor agents. XIII. Indole derivatives related to Lonidamine

The synthesis and the antitumor activities of 1-benzylindole-3-carboxylic acids are reported. Compound 16b, which bears at position 1 the same substituent as Lonidamine (1), proved to be the most active derivative.