935516-16-8

Basic information

• Product Name: C₂₃H₂₇F₄N₃O₃S
• CAS NO: 935516-16-8
• Molecular Weight: 501.545
• Mol File: 935516-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇F₄N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇F₄N₃O₃S(935516-16-8)
• EPA Substance Registry System: C₂₃H₂₇F₄N₃O₃S(935516-16-8)

Safety Data

• Hazardous Substances Data: 935516-16-8(Hazardous Substances Data)

Upstream product

• 116548-04-0 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 771572-85-1 (2-chloro-6-(trifluoromethyl)pyridin-3-yl)methanamine 
• 386704-06-9 2-chloro-6-(trifluoromethyl)nicotinonitrile 
• 935513-62-5 C₁₇H₁₆ClF₄N₃O₃S 
• 214907-15-0 (E)-tertiobutyl vinyl boronic acid 

Relevant articles and documents

2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists

A series of 2-alkyl/alkenyl pyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Multiple compounds showed excellent and stereospecific TRPV1 antagonism with better potency than previous lead 2. Among them, compound 15f demonstrated a strong analgesic profile in a rat neuropathic pain model and blocked capsaicin-induced hypothermia in a dose-dependent manner. Docking analysis of (S)-15f with our hTRPV1 homology model provided insight into its specific binding mode.