935657-73-1Relevant academic research and scientific papers
Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring
Heimann, Dominik,Lueg, Corinna,De Vries, Henk,Frehland, Bastian,Schepmann, Dirk,Heitman, Laura H.,Wünsch, Bernhard
, p. 1697 - 1705 (2017)
It has been reported that bioisosteric replacement of an 1,2,4-oxadiazole ring by an 1,3,4-oxadiazole ring leads to higher polarity, reduced metabolic degradation by human liver microsomes and reduced interaction with hERG channels. In a seven to eight st
An integration of condensation/Ullmann-type coupling/bicyclization sequences: Copper-catalyzed three-component direct synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones
Jia, Feng-Cheng,Xu, Cheng,Cai, Qun,Wu, An-Xin
supporting information, p. 9914 - 9916 (2014/08/18)
A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.
