93592-17-7Relevant academic research and scientific papers
Process for preparing 1-substituted-1,4-benzodiazepine derivatives
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, (2008/06/13)
Improvement in the production of psychotropic 1-substituted-1,3-dihydro-1,4-benzodiazepin-2-ones starting from 2-(1-substituted)amino-benzophenonimines through novel intermediates of the formula: STR1 (wherein R is hydrogen, methyl or benzyl, R1/sup
1-Azacycloalkyl-1,4-benzodiazepin-2-ones with Antianxiety-Antidepressant Actions
Sugasawa, Tsutomu,Adachi, Makoto,Sasakura, Kazuyuki,Matsushita, Akira,Eigyo, Masami,et al.
, p. 699 - 707 (2007/10/02)
A series of 1-azacycloalkyl-1,4-benzodiazepin-2-ones were synthesized from 1-azacycloalkyl-2-benzoylanilines 2-4 and corresponding imines 5 and 6 and then evaluated for their central nervous system activities.Pharmacological data showed that some of these
1,4-Benzodiazepine derivatives
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, (2008/06/13)
1,4-Benzodiazepine derivatives of the formula: STR1 (in which R1 is pyrrolidinyl or piperidinyl each optionally substituted by C1-3 alkyl, phenyl-C1-3 alkyl, C1-5 alkanoyl, or C2-5 alkoxycarbonyl, R2 is hydrogen, hydroxy, or acetoxy, R3 is C1-3 alkyl, phenyl-C1-3 alkyl, or phenyl optionally substituted by one or two halogens, X is hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, trifluoromethyl, or di-C1-3 alkyl-amino, and n is 1 or 2) or pharmaceutically acceptable acid addition salts thereof, which are useful as a psychotropic agent such as anti-depressant or anxiolytic agent can be prepared from several routes.
