936024-96-3Relevant academic research and scientific papers
COMPOUNDS, COMPOSITIONALS, AND METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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, (2019/02/15)
In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer,
A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives
Zhichkin, Paul,Kesicki, Edward,Treiberg, Jennifer,Bourdon, Lisa,Ronsheim, Matthew,Ooi, Hua Chee,White, Stephen,Judkins, Angela,Fairfax, David
, p. 1415 - 1418 (2007/10/03)
Figure presented An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with α-amino acids followed by reductive cyclization affords enantiomerically pure (ee >93%) quinazoline-4-ones in good overall yield. A comparison with existing approaches indicates that this method is superior for hindered substrates.
