936114-93-1

Basic information

• Product Name: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone
• Synonyms: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone
• CAS NO: 936114-93-1
• Molecular Weight: 343.164
• Mol File: 936114-93-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone(936114-93-1)
• EPA Substance Registry System: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone(936114-93-1)

Safety Data

• Hazardous Substances Data: 936114-93-1(Hazardous Substances Data)

Upstream product

• 936114-30-6 methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate 
• 648424-62-8 (S)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)pyrrolidin-2-one 
• 17342-08-4 (S)-Pyroglutaminol 
• 149427-84-9 (S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one 
• 67036-44-6 methyl (S)-2-(5-oxopyrrolidin-2-yl)acetate 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 
• 72479-06-2 2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile 
• 936114-10-2 methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-41-9 methyl 5-amino-2-[(5S)-5-{[(tert-butyl)dimethylsilyiloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-46-4 methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate 

Downstream Products

• 936114-51-1 (5S)-5-ethenyl-1-[4-iodo-2-formylphenyl]-2-pyrrolidinol 

Relevant articles and documents

An asymmetric total synthesis of martinellic acid

We describe an asymmetric total synthesis of the pyrrolo[3,2-c]quinoline natural product martinellic acid starting from pyrroglutamic acid. A convergent strategy involving a Pd-catalyzed aryl amination reaction of a chiral, non-racemic pyrrolidine derivative incorporates the C2-chiral center which controls the remaining two stereocenters. Elaboration of this adduct through a Grieco-elimination sets the stage for a diastereoselective intramolecular [3+2] azomethine ylide-alkene cycloaddition and the construction of the remaining two chiral centers. Elaboration of the cycloadduct and incorporation the prenyl guanidine units delivered martinellic acid after removal of the protecting groups.