936183-32-3Relevant academic research and scientific papers
Catalytic enantioselective synthesis of flavanones and chromanones
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Page/Page column 15, (2009/10/21)
Various chromanone, flavanone and abyssinone compounds as can be prepared enantioselectively using a chiral thiourea catalyst.
Asymmetrie synthesis of fluorinated flavanone derivatives by an organocatalytic tandem intramolecular oxa-michael Addition/electrophilic fluorination reaction by using bifunctional cinchona alkaloids
Wang, Hai-Feng,Cui, Hai-Feng,Chai, Zhuo,Li, Peng,Zheng, Chang-Wu,Yang, Ying-Quan,Zhao, Gang
supporting information; experimental part, p. 13299-13303+13273 (2010/06/17)
"Chemical Equation Presented" A bifunetional quinidine derivative, containing a trifluoromethyl group, was found to catalyze a tandem intramolecular oxa-Michael addition/electrophilic fluorination reaction of acti-vated α,β-unsaturated ketones (see scheme). A series of chiral fluorinated flavanone derivatives were obtained in excellent yields and with high enantioselectivities.
Catalytic enantioselective synthesis of flavanones and chromanones
Biddle, Margaret M.,Lin, Michael,Scheidt, Karl A.
, p. 3830 - 3831 (2008/02/04)
The enantioselective synthesis of flavanones and chromanones is described. Bifunctional thiourea catalysts promote an asymmetric oxo-conjugate addition to a β-ketoester alkylidene in high yields with excellent enantioselectivity (80-94% ee) for aryl and alkyl substrates. Decarboxylation of the β-ketoester proceeds smoothly in a one-pot procedure to afford the enantioenriched flavanones and chromanones. Copyright
