936210-30-9Relevant academic research and scientific papers
Total synthesis and cytotoxicity of (+)- and (-)-goniodiol and 6-epi-goniodiol. Construction of α,β-unsaturated lactones by ring-closing metathesis
Nakashima, Katsuyuki,Kikuchi, Naoki,Shirayama, Daisuke,Miki, Takuo,Ando, Kazuhiro,Sono, Masakazu,Suzuki, Shinya,Kawase, Masaki,Kondoh, Masuo,Sato, Masao,Tori, Motoo
, p. 387 - 394 (2008/02/11)
(+)-Goniodiol, a potent and selective cytotoxin, and (-)-6-epi-goniodiol, as well as their enantiomers, have been synthesized starting from cinnamyl alcohol. The key steps of the synthesis were Sharpless asymmetric epoxidation and cyclization of an acrylate derivative using ring-closing metathesis reaction. The cytotoxicity of both enantiomers of goniodiol and 6-epi-goniodiol against HL-60 cells was examined.
