936231-14-0

Basic information

• Product Name: 5-methoxy-1-phenyl-1H-indole
• Synonyms: 5-methoxy-1-phenyl-1H-indole
• CAS NO: 936231-14-0
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223
• Mol File: 936231-14-0.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methoxy-1-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-1-phenyl-1H-indole(936231-14-0)
• EPA Substance Registry System: 5-methoxy-1-phenyl-1H-indole(936231-14-0)

Safety Data

• Hazardous Substances Data: 936231-14-0(Hazardous Substances Data)

Upstream product

• 1006-94-6 5-methoxylindole 
• 108-86-1 bromobenzene 
• 115-86-6 phosphoric acid triphenyl ester 
• 591-50-4 iodobenzene 
• 1207743-69-8 2-(2-bromo-5-methoxyphenyl)ethylamine hydrobromide 
• 108-95-2 phenol 
• 2042-37-7 o-cyanobromobenzene 
• 299914-37-7 2-(5-methoxy-1H-indol-1-yl)benzonitrile 
• 98-80-6 phenylboronic acid 

Downstream Products

• 64053-60-7 5-methoxy-1-phenylindolin-2-one 
• 1259658-97-3 1,2-diphenyl-5-methoxy-1H-indole 
• 1394402-22-2 5-methoxy-1-phenyl-1H-indole-3-carbonitrile 

Relevant articles and documents

Preparation method of N-arylindole under copper catalysis

The invention provides a preparation method of N-arylindole under copper catalysis. The preparation method comprises the following steps: S1, selecting a proper amount of a reaction reagent, a catalyst, a solvent and the like; S2, sequentially adding the

Tryptamine Synthesis by Iron Porphyrin Catalyzed C?H Functionalization of Indoles with Diazoacetonitrile

The functionalization of C?H bonds with non-precious metal catalysts is an important research area for the development of efficient and sustainable processes. Herein, we describe the development of iron porphyrin catalyzed reactions of diazoacetonitrile with N-heterocycles yielding important precursors of tryptamines, along with experimental mechanistic studies and proof-of-concept studies of an enzymatic process with YfeX enzyme. By using readily available FeTPPCl, we achieved the highly efficient C?H functionalization of indole and indazole heterocycles. These transformations feature mild reaction conditions, excellent yields with broad functional group tolerance, can be conducted on gram scale, and thus provide a unique streamlined access to tryptamines.

Palladium-Catalyzed C(sp2)-N Bond Cross-Coupling with Triaryl Phosphates

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(?-cinnamyl)Cl]2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.