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  • 115-86-6 Structure
  • Basic information

    1. Product Name: Triphenyl phosphate
    2. Synonyms: Altal;Celluflex TPP;celluflextpp;Disflamoll TP;disflamolltp;Dymel;Kronitex TPP;Phenyl phosphate ((PhO)3PO)
    3. CAS NO:115-86-6
    4. Molecular Formula: C18H15O4P
    5. Molecular Weight: 326.28
    6. EINECS: 204-112-2
    7. Product Categories: Flame retardants;Functional Materials;Phosphates (Plasticizer);Plasticizer;AromaticsEPA;Method 507Volatiles/ Semivolatiles;500 Series Drinking Water Methods;Alpha Sort;Analytical Standards;Chemical Class;TP - TZ;T-ZAlphabetic;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds;AromaticsVolatiles/ Semivolatiles;organophosphorus compound;Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds;Flame retardant plasticizing agent
    8. Mol File: 115-86-6.mol
    9. Article Data: 100
  • Chemical Properties

    1. Melting Point: 48-50 °C(lit.)
    2. Boiling Point: 370 °C
    3. Flash Point: 435 °F
    4. Appearance: White/Crystalline Flakes
    5. Density: 1.2055
    6. Vapor Density: 11.3 (vs air)
    7. Vapor Pressure: 1.3 mm Hg ( 200 °C)
    8. Refractive Index: 1.563
    9. Storage Temp.: 2-8°C
    10. Solubility: H2O: soluble0.0019g/L at 20°C
    11. Water Solubility: insoluble
    12. Stability: Stable.
    13. Merck: 14,9742
    14. BRN: 1888236
    15. CAS DataBase Reference: Triphenyl phosphate(CAS DataBase Reference)
    16. NIST Chemistry Reference: Triphenyl phosphate(115-86-6)
    17. EPA Substance Registry System: Triphenyl phosphate(115-86-6)
  • Safety Data

    1. Hazard Codes: Xn,N,F,Xi
    2. Statements: 22-38-40-48/20/22-50/53-52/53-36/37/38-67-66-36-11-51/53
    3. Safety Statements: 36/37-61-60-24/25-22-36-26-16-24-9
    4. RIDADR: UN 3077 9/PG 3
    5. WGK Germany: 2
    6. RTECS: TC8400000
    7. TSCA: Yes
    8. HazardClass: 9
    9. PackingGroup: III
    10. Hazardous Substances Data: 115-86-6(Hazardous Substances Data)

115-86-6 Usage

Chemical Description

Triphenyl phosphate is an ester of phosphoric acid with three phenyl groups attached to the phosphate group.

Description

Triphenyl phosphate (TPP) is an aryl phosphate resulting from the formal condensation of phosphoric acid with three moles of phenol. It is a colorless crystalline powder with a faint, phenol-like odor and has a role as a flame retardant and a plasticizer. Triphenyl phosphate is practically insoluble in water and very soluble in carbon tetrachloride, as well as in most lacquers, solvents, thinners, and oils, including alcohol, benzene, ether, chloroform, and acetone. It begins to decompose at about 600 °C in inert gas and undergoes complete combustion in the range of 800–900 °C in a large excess of air. Hydrolysis of TPP occurs very slowly in acidic or neutral solutions but rapidly in alkaline solutions.

Uses

Used in Electrical and Automobile Industries:
Triphenyl phosphate is used as a flame retardant in phenolicand phenylene oxide-based resins for the manufacture of electrical and automobile components. It provides nonflammable properties to these components, enhancing their safety and performance.
Used in Textile Industry:
Triphenyl phosphate is used as a flame retardant for auto upholstery, ensuring the safety and fire resistance of vehicle interiors.
Used in Plastics Industry:
Triphenyl phosphate is used as a nonflammable plasticizer in cellulose acetate for photographic films, improving the flexibility and workability of the material while maintaining its fire-resistant properties.
Used in Construction Industry:
Triphenyl phosphate has been used to impregnate roofing paper, providing additional fire protection to the roofing material.
Used in Coatings and Adhesives:
Triphenyl phosphate is used as a plasticizer in various lacquers and varnishes, enhancing their flexibility and workability.
Used in Lubricants and Hydraulic Fluids:
Triphenyl phosphate is used as a component of lubricating oil and hydraulic fluids, improving their performance and reducing wear.
Used in Insecticidal Compositions:
Triphenyl phosphate is used in the insecticidal composition, providing additional benefits to the formulation.
Used in Hydraulic Liquids, Adhesives, Inks, and Coatings:
Triphenyl phosphate is used as a plasticizer in these applications, improving the flexibility and workability of the materials.
Used as a Substitute for Camphor in Celluloid Materials:
Triphenyl phosphate is used as a substitute for camphor in celluloid materials to make them stable and fireproof, enhancing their safety and performance.

Preparation

Triphenyl phosphate is prepared by reacting phosphorus pentoxide and phenol (Budavari, 2001), or by reacting phosphorus oxychloride and phenol (Snyder, 1990). On a larger scale phosphorus oxychloride and phenol are reacted in an esterification tank with heating. The HCL formed is trapped and condensed, while the crude triphenyl phosphate runs into a large tank where it is purified.

Reactivity Profile

Organophosphates, such as Triphenyl phosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Toxic by inhalation. Cholinesterase inhibitor. Questionable carcinogen.

Health effects

Non-industrial:An allergic reaction in a 67-year old woman to spectacle frames containing triphenyl phosphate was reported. Patch tests with analytical grade triphenyl phosphate in that individual indicated a reaction at concentrations as low as 0.05%. This observation was confirmed in another male patient (Carlsen et al 1986).Industrial:Occupational exposure of men engaged in manufacturing triphenyl phosphate produced a statistically significant reduction in erythrocyte acetylcholinesterase activity and plasma cholinesterase activity. There was no evidence of adverse clinical effects in men exposed to triphenyl phosphate for as long as 10 years. Exposure was to triphenyl phosphate mist, vapor, and dust at a weighted average air concentration of 3.5 mg/m3 (Sutton et al 1960).

Fire Hazard

Noncombustible solid. Incompatibility— none.

Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion. Absorbed slowly, particularly by skin contact. Not a potent cholinesterase inhibitor. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical. When heated to decomposition it emits toxic fumes of POx. See also TRITOLYL PHOSPHATE.

Potential Exposure

Triphenyl phosphate is used to impregnate roofing paper and as a fire-resistant plasticizer in plastics; for cellulose esters in lacquers and varnishes. Used in making adhesives, gasoline additives; flotation agents; insecticides, surfactants, antioxidants, and stabilizers. A substitute for camphor.

Source

Triphenyl phosphate was identified as a component in outer covers of brand-new computer video display units. Concentrations were estimated to be 8 to 10 and 0.3 to 0.5 wt % in 4 and 6 video display units, respectively. The concentrations of triphenyl phosphate in the remaining 8 video display units were <0.02 wt % (Carlsson et al., 2000).

Environmental fate

Chemical/Physical. When an aqueous solution containing triphenyl phosphate (0.1 mg/L) and chlorine (3 to 1,000 mg/L) was stirred in the dark at 20 °C for 24 h, the benzene ring was substituted with one to three chlorine atoms (Ishikawa and Baba, 1988). The reported hydrolysis half-lives at pH values of 8.2 and 9.5 were 7.5 and 1.3 d, respectively (Howard and Doe, 1979). Decomposes at temperatures greater than 410 °C (Dobry and Keller, 1957)

Metabolism

Rat liver microsomal enzymes degraded triphenyl phosphate in the presence of NADPH, but also in the absence of NADPH. The product of incubation was diphenyl phosphate. It was clear that the reaction was cytochrome P-450-linked since the reaction was inhibited by carbon monoxide (Sasaki et al 1984). Goldfish liver microsomes metabolized only about 10% of triphenyl phosphate (Sasaki et al 1985). Houseflies treated with triphenyl phosphate were analyzed after 24 h and the presence of diphenyl p-hydroxyphenyl phosphate was confirmed (Eto et al 1975).

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

Crystallise the phosphate from EtOH or pet ether (b 60-80o)/EtOH. [Cox & Westheimer J Am Chem Soc 80 5441 1958, Krishnakumar & Sharma Synthesis 558 1983, Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 6 III 658, 6 IV 720.]

Toxicity evaluation

Triphenyl phosphate(TPP) is neurotoxic, causing paralysis at high dosages. Like tri-o-cresyl phosphate (TOCP), it is a cholinesterase inhibitor. The acute oral toxicity is low. The acute toxicity via subcutaneous administration is low to moderate. The toxic symptoms from high dosages in test animals were tremor, diarrhea, muscle weakness, and paralysis.LD50 value, oral (mice): 1320 mg/kgLD50 value, subcutaneous (cats): 100 mg/kgCleveland et al. (1986) investigated the acute and chronic toxicity to various species of freshwater fish of phosphate ester compounds containing TPP. The adverse toxic effects occurred at exposure concentrations of 0.38–1.0 mg/L.

Incompatibilities

Incompatible with strong oxidizers; strong acids; nitrates may cause fire or explosions. Phosphates are incompatible with antimony pentachloride, magnesium, silver nitrate, zinc acetate.

Waste Disposal

Incinerate in furnace equipped with alkaline scrubber.

Check Digit Verification of cas no

The CAS Registry Mumber 115-86-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 115-86:
(5*1)+(4*1)+(3*5)+(2*8)+(1*6)=46
46 % 10 = 6
So 115-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H15O4P/c19-23(20-16-10-4-1-5-11-16,21-17-12-6-2-7-13-17)22-18-14-8-3-9-15-18/h1-15H

115-86-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L08130)  Triphenyl phosphate, 98%   

  • 115-86-6

  • 250g

  • 176.0CNY

  • Detail
  • Alfa Aesar

  • (L08130)  Triphenyl phosphate, 98%   

  • 115-86-6

  • 1000g

  • 503.0CNY

  • Detail
  • Supelco

  • (442829)  Triphenylphosphate  analytical standard

  • 115-86-6

  • 000000000000442829

  • 234.00CNY

  • Detail
  • Aldrich

  • (241288)  Triphenylphosphate  ≥99%

  • 115-86-6

  • 241288-50G

  • 348.66CNY

  • Detail

115-86-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name triphenyl phosphate

1.2 Other means of identification

Product number -
Other names tricresyl phosphate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115-86-6 SDS

115-86-6Synthetic route

triphenyl phosphite
101-02-0

triphenyl phosphite

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With bis(2,4,6-triisopropylphenyl) telluroxide In acetonitrile at 20℃; for 0.5h;100%
With 1-methyl-3-(4-((2,4,6-triisopropylphenyl)tellanyl)benzyl)-1H-imidazol-3-ium hexafluorophosphate; Rose Bengal lactone at 15℃; for 2.5h; Reagent/catalyst; Irradiation; Ionic liquid;99%
With iodosylbenzene; Montmorillonite K10 In acetonitrile at 20℃; for 2h;93%
chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

phenol
108-95-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With titanium(IV) tetrabutoxide; triethylamine In dichloromethane at 20℃; for 1h;99%
With titanium tetrachloride; triethylamine In tetrahydrofuran at 20℃; for 1h;98%
With molybdenum(VI) tetrachloride oxide; triethylamine In dichloromethane at 20℃; for 1h;98%
O,O,O-triphenyl selenophosphate
7248-72-8

O,O,O-triphenyl selenophosphate

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With Montmorillonite K10; iodoxybenzene In acetonitrile at 20℃; for 5h;96%
diphenyl hydrogen phosphate
838-85-7

diphenyl hydrogen phosphate

Diphenyliodonium triflate
66003-76-7

Diphenyliodonium triflate

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With triethylamine In toluene at 110℃; for 3h; Inert atmosphere;96%
sodium phenoxide
139-02-6

sodium phenoxide

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With Amberlyst A-26 chloride; trichlorophosphate In benzene for 1h; Ambient temperature;94%
With PEG-400; trichlorophosphate In chloroform; water at 30 - 45℃; for 1.5h;90%
With trichlorophosphate In dichloromethane for 2h; Heating;90%
diphenyl hydrogen phosphate
838-85-7

diphenyl hydrogen phosphate

phenol
108-95-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With tetrachloromethane; copper; sodium carbonate; triethylamine In dichloromethane at 100℃; for 12h; Sealed tube;93%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 6h; Inert atmosphere;27%
With N,N-dimethyl-aniline; 1,1'-carbonyldiimidazole In acetonitrile at 20℃; for 12h; Inert atmosphere;11%
phenol
108-95-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With phosphorus pentachloride In methanol; dichloromethane92%
With trichlorophosphate; aluminium trichloride In water; toluene91%
With sodium hydroxide; trichlorophosphate for 2h; Esterification; Microwave irradiation;90%
diphenyl phosphoryl azide
26386-88-9

diphenyl phosphoryl azide

phenol
108-95-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With sodium carbonate; zinc(II) acetylacetonate In 1,4-dioxane at 60℃; for 24h; Inert atmosphere;92%
triphenyl phosphite
101-02-0

triphenyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

dimethyl phenylphosphonite
18351-42-3

dimethyl phenylphosphonite

C

diphenyl methylphosphonate
7526-26-3

diphenyl methylphosphonate

D

phenol
108-95-2

phenol

Conditions
ConditionsYield
Stage #1: triphenyl phosphite; methyl iodide at 20 - 240℃;
Stage #2: phosphorous acid trimethyl ester at 210 - 260℃; for 4h; Product distribution / selectivity;
A n/a
B n/a
C 91.8%
D n/a
triphenyl phosphite
101-02-0

triphenyl phosphite

1-Nitropropen
3156-70-5

1-Nitropropen

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

diphenyl (1-cyanoethyl)phosphonate
81913-76-0

diphenyl (1-cyanoethyl)phosphonate

Conditions
ConditionsYield
for 48h; Ambient temperature;A 81%
B 80%
pentaphenoxyphosphorane
19613-06-0

pentaphenoxyphosphorane

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
In acetonitrile Reduction; Electrochemical reaction; Pt electrode;80%
4-Phenylphenol
92-69-3

4-Phenylphenol

phenol
108-95-2

phenol

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

biphenyl-4-yl diphenyl phosphate
17269-99-7

biphenyl-4-yl diphenyl phosphate

C

bis(para-biphenyl)phenyl phosphate
17270-00-7

bis(para-biphenyl)phenyl phosphate

Conditions
ConditionsYield
Stage #1: 4-Phenylphenol With magnesium chloride; trichlorophosphate at 0℃; for 2h; Inert atmosphere;
Stage #2: phenol at 25℃; Temperature;
A 5.2%
B 79%
C 14.8%
Stage #1: 4-Phenylphenol With manganese(ll) chloride; trichlorophosphate In dichloromethane at 0℃; for 2h; Inert atmosphere; Industry scale;
Stage #2: phenol In dichloromethane at 0 - 25℃; Product distribution / selectivity; Inert atmosphere; Industry scale;
A 20.9 %Chromat.
B 67 %Chromat.
C 10 %Chromat.
phenol
108-95-2

phenol

A

triphenyl phosphite
101-02-0

triphenyl phosphite

B

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With pyridine In acetonitrile at 50℃; electrosynthesis;A 78%
B 20%
O,O,O-triphenyl phosphorothioate
597-82-0

O,O,O-triphenyl phosphorothioate

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With iodosylbenzene; Montmorillonite K10 In acetonitrile at 20℃; for 3h;72%
With ozone In dichloromethane at -75℃;54%
With 3-methylpyridazine-2-oxide In dichloromethane for 5h; Irradiation;32%
With pyridine; trifluoroacetic anhydride for 48h;10%
With 3-chloro-benzenecarboperoxoic acid at -5℃; Yield given;
diphenyl hydrogen phosphate
838-85-7

diphenyl hydrogen phosphate

phenylboronic acid
98-80-6

phenylboronic acid

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With oxygen; urea; copper(I) bromide In acetonitrile at 80℃; for 12h; Molecular sieve; Schlenk technique;65%
chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

methyl iodide
74-88-4

methyl iodide

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

diphenyl methylphosphonate
7526-26-3

diphenyl methylphosphonate

Conditions
ConditionsYield
Stage #1: chlorophosphoric acid diphenyl ester With potassium naphthalenide In tetrahydrofuran at -78℃; for 0.25h;
Stage #2: methyl iodide In tetrahydrofuran
A 10%
B 62%
[1,3]-dioxolan-2-one
96-49-1

[1,3]-dioxolan-2-one

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

A

bis(2-chloroethyl) phenyl phosphate
22564-57-4

bis(2-chloroethyl) phenyl phosphate

B

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

C

2-chloroethyl diphenyl phosphate
5314-06-7

2-chloroethyl diphenyl phosphate

Conditions
ConditionsYield
With guanidine hydrogen carbonate at 120℃; for 3h;A 3%
B 3%
C 59%
With lithium fluoride at 170℃; for 3h;A 10%
B 20%
C 35%
With lithium chloride at 170℃; for 3h;A 10%
B 18%
C 28%
trichloromethylphosphonous dichloride
3582-11-4

trichloromethylphosphonous dichloride

phenol
108-95-2

phenol

A

triphenyl phosphite
101-02-0

triphenyl phosphite

B

chloroform
67-66-3

chloroform

C

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
A 55.6%
B 34%
C 6.7%
C25H26O4P(1+)*ClH*Cl(1-)

C25H26O4P(1+)*ClH*Cl(1-)

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

1-chlorobicyclo[2.2.1]heptane
765-67-3

1-chlorobicyclo[2.2.1]heptane

Conditions
ConditionsYield
at 113 - 140℃;A n/a
B 46%
4-Phenylphenol
92-69-3

4-Phenylphenol

phenol
108-95-2

phenol

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

tris(4-biphenyl) phosphate
3871-23-6

tris(4-biphenyl) phosphate

C

biphenyl-4-yl diphenyl phosphate
17269-99-7

biphenyl-4-yl diphenyl phosphate

D

bis(para-biphenyl)phenyl phosphate
17270-00-7

bis(para-biphenyl)phenyl phosphate

Conditions
ConditionsYield
Stage #1: 4-Phenylphenol With magnesium chloride; trichlorophosphate at 25℃; for 2h; Inert atmosphere;
Stage #2: phenol at 25℃; Temperature;
A 34.8%
B 5%
C 43%
D 15.4%
triphenyl phosphite ozonide
29833-83-8

triphenyl phosphite ozonide

6-isopropylidene-2,2-dimethyl-4-trimethylsiloxy-1,3-dioxine

6-isopropylidene-2,2-dimethyl-4-trimethylsiloxy-1,3-dioxine

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

6-(1-hydroxy-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxin-4-one

6-(1-hydroxy-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxin-4-one

C

6-(1-hydroperoxy-1-methyl)ethyl-2,2-dimethyl-1,3-dioxin-4-one
345304-95-2

6-(1-hydroperoxy-1-methyl)ethyl-2,2-dimethyl-1,3-dioxin-4-one

D

6-(1-(diphenylphosphoryl)peroxy-1-methyl)ethyl-2,2-dimethyl-1,3-dioxin-4-one
345305-02-4

6-(1-(diphenylphosphoryl)peroxy-1-methyl)ethyl-2,2-dimethyl-1,3-dioxin-4-one

Conditions
ConditionsYield
With triphenyl phosphite ozonide In dichloromethane at -78 - 20℃; for 1h; Product distribution;A n/a
B 11%
C 42%
D 19%
Triphenyl(diethoxyphosphorylimido)phosphate
126793-90-6

Triphenyl(diethoxyphosphorylimido)phosphate

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
at 140℃; for 5h;15%
at 140℃; for 5h; thermal decomposition; other educts, other reaction times, other temperatures, also in solvent decalin;15%
bromobenzene
108-86-1

bromobenzene

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With potassium phosphate; copper; copper dichloride UV-Licht;
diphenylether
101-84-8

diphenylether

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With phosphorus pentoxide at 130 - 150℃;
diphenyl sulfite
4773-12-0

diphenyl sulfite

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With trichlorophosphate at 120 - 130℃;
With phosphorus pentachloride at 120 - 130℃;
diphenyl diethylphosphoramidate
6214-04-6

diphenyl diethylphosphoramidate

A

hexaethylphosphorous triamide
2622-07-3

hexaethylphosphorous triamide

B

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
bei der Destillation im Vakuum;
phenyl chlorosulphinate
13165-73-6

phenyl chlorosulphinate

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With trichlorophosphate
trichloroacetyl-triphenoxyphosphoranyliden-amine
94578-40-2

trichloroacetyl-triphenoxyphosphoranyliden-amine

A

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

B

trichloroacetonitrile
545-06-2

trichloroacetonitrile

Conditions
ConditionsYield
at 300℃;
aluminium(III) phenoxide
15086-27-8

aluminium(III) phenoxide

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With phosphorus pentoxide at 300℃;
O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phenol
108-95-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Conditions
ConditionsYield
With sodium hydroxide
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12N3O15Tm

H12N3O15Tm

C54H45N3O21P3Tm

C54H45N3O21P3Tm

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;99.8%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

ErH12N3O15

ErH12N3O15

C54H45ErN3O21P3

C54H45ErN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;99.2%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

2-phenylaniline
90-41-5

2-phenylaniline

N-(2-biphenyl)aniline
35887-50-4

N-(2-biphenyl)aniline

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate at 130℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;99%
With N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; [Pd(π-cinnamyl)Cl]2 at 130℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;99%
6-aminoquinoline
580-15-4

6-aminoquinoline

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

N-phenylquinolin-6-amine
70682-98-3

N-phenylquinolin-6-amine

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate at 130℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;99%
With N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; [Pd(π-cinnamyl)Cl]2 at 130℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;99%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

EuH12N3O15

EuH12N3O15

C54H45EuN3O21P3

C54H45EuN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98.6%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12N3O15Yb

H12N3O15Yb

C54H45N3O21P3Yb

C54H45N3O21P3Yb

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98.3%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

DyH12N3O15

DyH12N3O15

C54H45DyN3O21P3

C54H45DyN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98.1%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

(trimethylsilyl)methylmagnesium chloride
13170-43-9

(trimethylsilyl)methylmagnesium chloride

benzyltrimethylsilane
770-09-2

benzyltrimethylsilane

Conditions
ConditionsYield
bis(acetylacetonate)nickel(II) In diethyl ether for 15h; Ambient temperature;98%
indole
120-72-9

indole

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

1-phenyl-1H-indole
16096-33-6

1-phenyl-1H-indole

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate at 130℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;98%
With N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; [Pd(π-cinnamyl)Cl]2 at 130℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;98%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

C54H45LaN3O21P3

C54H45LaN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

CeH12N3O15

CeH12N3O15

C54H45CeN3O21P3

C54H45CeN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12N3O15Pr

H12N3O15Pr

C54H45N3O21P3Pr

C54H45N3O21P3Pr

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;98%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

GdH12N3O15

GdH12N3O15

C54H45GdN3O21P3

C54H45GdN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;97.2%
3-chloro-2,5-bis(2-methylpropyl)pyrazine
19803-49-7

3-chloro-2,5-bis(2-methylpropyl)pyrazine

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

2,5-Diisobutyl-3-phenoxy-pyrazine
84022-56-0

2,5-Diisobutyl-3-phenoxy-pyrazine

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl acetamide for 1h; Heating;97%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12N3NdO15

H12N3NdO15

C54H45N3NdO21P3

C54H45N3NdO21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;95.3%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

4-nitrophenyl phenyl ether
620-88-2

4-nitrophenyl phenyl ether

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide for 1h; Heating;95%
5-methoxylindole
1006-94-6

5-methoxylindole

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

5-methoxy-1-phenyl-1H-indole
936231-14-0

5-methoxy-1-phenyl-1H-indole

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate In neat (no solvent) at 130℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube;95%
With N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; [Pd(π-cinnamyl)Cl]2 In neat (no solvent) at 130℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube;95%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12N3O15Sm

H12N3O15Sm

C54H45N3O21P3Sm

C54H45N3O21P3Sm

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;95%
2-Chloroquinoline
612-62-4

2-Chloroquinoline

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

2-(2-quinolinyl)phenol
40515-82-0

2-(2-quinolinyl)phenol

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide for 1h; Heating;94%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

tris(hydroxymethyl)phosphine sulfide
1067-13-6

tris(hydroxymethyl)phosphine sulfide

1-oxo-4-sulfanylidene-2,6,7-trioxa-1,4-diphosphabicyclo[2.2.2]octane

1-oxo-4-sulfanylidene-2,6,7-trioxa-1,4-diphosphabicyclo[2.2.2]octane

Conditions
ConditionsYield
With sodium methylate at 150℃; for 8h; Reagent/catalyst; Temperature; Inert atmosphere;93.8%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

H12LuN3O15

H12LuN3O15

C54H45LuN3O21P3

C54H45LuN3O21P3

Conditions
ConditionsYield
In acetone for 0.25h; Sonication; Glovebox;93.3%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

4,4-ethylenedioxy-piperidine
177-11-7

4,4-ethylenedioxy-piperidine

8-phenyl-1,4-dioxa-8-azaspiro[4,5]decane
198649-62-6

8-phenyl-1,4-dioxa-8-azaspiro[4,5]decane

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium carbonate at 130℃; for 18h; Schlenk technique; Inert atmosphere; Sealed tube;93%
With N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; [Pd(π-cinnamyl)Cl]2 at 130℃; for 18h; Schlenk technique; Inert atmosphere; Sealed tube;93%
trimethylaluminium dimer

trimethylaluminium dimer

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

Me3Al*OP(OPh)3

Me3Al*OP(OPh)3

Conditions
ConditionsYield
In hexane; toluene N2-atmosphere; addn. of hexane soln. of AlMe3 (10% excess) to phosphate ester soln. (MePh) at cooling, warming to room temp.; evapn. (vac.); elem. anal.;92%

115-86-6Related news

Bioremediation of Triphenyl phosphate (cas 115-86-6) by Brevibacillus brevis: Degradation characteristics and role of cytochrome P450 monooxygenase08/31/2019

Triphenyl phosphate (TPHP) has been detected with increasing frequency in environmental samples, which has aroused great attention regarding its potential adverse effects. In this study, biodegradation of TPHP by Brevibacillus brevis was investigated. The results revealed that the highest degrad...detailed

Neonatal Triphenyl phosphate (cas 115-86-6) and its metabolite diphenyl phosphate exposure induce sex- and dose-dependent metabolic disruptions in adult mice☆08/30/2019

The widespread application of organophosphorous flame retardants (OPFRs) has led to considerable human exposure, with major concerns regarding their health risks. Herein, we investigate the effects of triphenyl phosphate (TPP), one of the most widely used OPFRs, and one of its main metabolite di...detailed

Degradation of the flame retardant Triphenyl phosphate (cas 115-86-6) by ferrous ion-activated hydrogen peroxide and persulfate: Kinetics, pathways, and mechanisms08/29/2019

The efficacies of ferrous ion-activated hydrogen peroxide (Fe2+/H2O2, Fenton) and persulfate (Fe2+/S2O82−, Fe2+/PS) processes for degrading triphenyl phosphate (TPhP) in aqueous solutions were systemically investigated and compared. Both Fenton and Fe2+/PS processes can effectively degrade TPhP ...detailed

Acute exposure to Triphenyl phosphate (cas 115-86-6) (TPhP) disturbs ocular development and muscular organization in zebrafish larvae08/28/2019

Triphenyl phosphate (TPhP) is an organophosphate flame retardant that is frequently detected in the environments. TPhP exposure is known to cause developmental toxicity. However, the underlying molecular mechanisms remain underestimated. In the present study, zebrafish embryos were acutely expos...detailed

Triphenyl phosphate (cas 115-86-6) end-capped dicyanomethylene-4H-pyran as a near infrared fluorescent sensor for lysozyme in urine sample08/27/2019

A dicyano-methylene-4H-pyran (DCM)-based fluorescent probe DCPOP was designed for detecting lysozyme in urine sample. DCPOP showed obvious NIR emission (> 650 nm) avoiding the background fluorescence of urine (450 ˜ 600 nm). Compared to its mimic (DCPO), DCPOP has a big end-capped triphenyl phos...detailed

Effects of Triphenyl phosphate (cas 115-86-6) exposure during fetal development on obesity and metabolic dysfunctions in adult mice: Impaired lipid metabolism and intestinal dysbiosis☆08/26/2019

Previous in vitro studies have implied that triphenyl phosphate (TPHP) may act as an obesogen. However, its specific contributions to the progression of obesity and related metabolic diseases are still unclear in vivo in mice. In this study, we evaluated the effects of in utero and lactational e...detailed

Degradation of Triphenyl phosphate (cas 115-86-6) (TPhP) by CoFe2O4-activated peroxymonosulfate oxidation process: Kinetics, pathways, and mechanisms08/25/2019

The aryl organophosphate flame retardant triphenyl phosphate (TPhP) has been frequently detected in environment and biota, and the potential risks of TPhP to aquatic organisms have also been demonstrated. The degradation of TPhP by CoFe2O4 activated peroxymonosulfate (PMS) was studied in this wo...detailed

Developmental neurotoxicity of Triphenyl phosphate (cas 115-86-6) in zebrafish larvae08/24/2019

Triphenyl phosphate (TPhP), a typical organophosphate ester, is frequently detected in the environment and biota samples. It has been implicated as a neurotoxin as its structure is similar to neurotoxic organophosphate pesticides. The purpose of the present study was to investigate its potential...detailed

Filling natural microtubules with Triphenyl phosphate (cas 115-86-6) for flame-retarding polymer composites08/23/2019

Phosphorus flame retardants can provide polymers with flame retardancy, but they often compromise the polymers’ mechanical performance due to plasticization. This problem is addressed in this study by filling and sealing triphenyl phosphate into natural microtubules of ∼100 µm in length, 10–...detailed

Optical toxicity of Triphenyl phosphate (cas 115-86-6) in zebrafish larvae08/22/2019

Triphenyl phosphate (TPhP) has been shown to cause developmental neurotoxicty. Considering the visual system is a sensitive target, in the present study, we investigated the potential toxicity of TPhP on the visual development and function in zebrafish larvae. Embryos were exposed to 0, 0.1, 1, ...detailed

115-86-6Relevant articles and documents

Plumb,Griffin

, p. 2908 (1963)

CHEMILUMINESCENCE UPON DECOMPOSITION OF THE OZONIDE OF TRIPHENYLPHOSPHITE

Shereshovets, V. V.,Ostakhov, S. S.,Korotaeva, N. M.,Sharipov, G.L.,Kazakov, V. P.,et al.

, p. 2460 - 2462 (1989)

We have studied the spectral composition of luminescence and the kinetics of attenuation of chemiluminescence upon thermal decomposition of the ozonide of triphenylphosphite.We have established that the emitter of chemiluminescence in the IR region is singlet oxygen, and the emitter of chemiluminescence in the visible region is triphenylphosphate.

Aerobic Oxidation of Phosphite Esters to Phosphate Esters by Using an Ionic-Liquid-Supported Organotelluride Reusable Catalyst

Mihoya, Aya,Shibuya, Yuga,Ito, Akane,Toyoda, Anna,Oba, Makoto,Koguchi, Shinichi

, p. 2043 - 2045 (2020)

We describe the synthesis of an ionic-liquid (IL)-supported organotelluride catalyst and its application as a recyclable catalyst for the aerobic oxidation of phosphite esters to phosphate esters. This method shows high conversion rates, allows the ready isolation and purification of the resulting products, and exhibits good reusability of the catalyst.

Tellurium tetrachloride as an efficient chlorinating agent for di- or trialkyl phosphites: Novel synthesis of dialkyl chlorophosphates

Koh,Oh

, p. 1771 - 1774 (1993)

Various dialkyl chlorophosphates are prepared by the reaction of TeCl4 with di- or trialkyl phosphites in good yields.

Iodosobenzene and iodoxybenzene as reagents for oxygen transfer in organophosphorus chemistry

Mielniczak,Lopusiński

, p. 505 - 508 (2001)

The application of iodosobenzene (1) and iodoxybenzene (2) for the oxidation reaction of phosphorous, phosphorothiono and phosphoroseleno compounds into the corresponding ≡P(O) analogs is demonstrated. Retention of configuration at the phosphorus atom and full stereoselectivity of these reactions in model diastereoisomeric cis- and trans-2-phenylamino-2-thiono-4-methyl-1.3.2-dioxaphosphorinans (30) as well cis- and trans-2-phenylamino-2-seleno-4-methyl-1.3.2-dioxaphosphorinans (31) systems, are demonstrated.

Preparation of Flame-Resistant Liquids Based on Mixed Tri(phenyl, p-tert-butylphenyl) Phosphates by Transesterification of Triphenyl Phosphate with p-tert-Butylphenol

Karchevskaya, O. G.,Korneeva, G. A.,Kron, T. E.,Noskov, Yu. G.

, p. 1237 - 1243 (2020)

Abstract: The possibility of controlling the composition of a mixture of triphenyl phosphate, p-tert-butylphenyl diphenyl phosphate, di(p-tert-butylphenyl)phenyl phosphate, and tri(p-tert-butylphenyl) phosphate, formed by transesterification of triphenyl phosphate with p-tert-butylphenol, was demonstrated. The amount of p-tert-butylphenol necessary for transesterification of triphenyl phosphate to yield a mixture of phosphates of required composition was determined. If necessary, the composition of the phosphates can be adjusted by selective distillation of triphenyl phosphate in a vacuum.

Zero-Valent Amino-Olefin Cobalt Complexes as Catalysts for Oxygen Atom Transfer Reactions from Nitrous Oxide

Gianetti, Thomas L.,Rodríguez-Lugo, Rafael E.,Harmer, Jeffrey R.,Trincado, Monica,Vogt, Matthias,Santiso-Quinones, Gustavo,Grützmacher, Hansj?rg

, p. 15323 - 15328 (2016)

The synthesis and characterization of several zero-valent cobalt complexes with a bis(olefin)-amino ligand is presented. Some of these complexes proved to be efficient catalysts for the selective oxidation of secondary and allylic phosphanes, as well as diphosphanes, even with a direct P?P bond. With 5 mol % catalyst loadings the oxidations proceed under mild conditions (25–70 °C, 7–22 h, 2 bar N2O) and afford good to excellent yields (65–98 %). In this process, the greenhouse gas N2O is catalytically converted into benign N2and added-value organophosphorus compounds, some of which are difficult to obtain otherwise.

Evaluation of kinetic parameters from the synthesis of triaryl phosphates using reaction calorimetry

Machado e Silva, Carlos F. Pinto,Da Silva, Joao F. Cajaiba

, p. 829 - 832 (2002)

Triaryl phosphates were prepared by a "one-pot" methodology through the reaction of sodium phenoxides with phosphorus oxychloride. This system can be described as a semi-batch reaction, where the phenoxides were synthesized inside the reactor anda solution of phosphorus oxychloride in toluene was added continuously through a pump. These highly exothermic reactions were performed in a Mettler RC-1 reaction calorimeter. The aim of this work was to evaluate the reaction rate and the reaction rate constant through the study of the rate of heat release. Although the phenoxides react almost immediately with phosphorus oxychloride, it was possible to notice the slight differences among the sodium phenoxides studied. The phenoxide bearing an electron-donating group (methoxy) was the most reactive, and the one bearing an electron-withdrawing group (nitro) was the least reactive one. The reactions could be considered to be feed-controlled. It was demonstrated that the reaction temperature does not affect the reaction rate and reaction rate constant in the same way that the feed rate of the phosphorus oxychloride does.

-

Poshkus et al.

, p. 5022,5026 (1958)

-

Quenching of a photosensitized dye through single-electron transfer from trivalent phosphorus compounds

Yasui, Shinro,Tsujimoto, Munekazu,Itoh, Kenji,Ohno, Atsuyoshi

, p. 4715 - 4720 (2000)

Various types of trivalent phosphorus compounds 1 undergo single-electron transfer (SET) to the photoexcited state of rhodamine 6G (Rho+(*)) in aqueous acetonitrile to quench the fluorescence from Rho+(*). The rate constants k(p) for the overall SET process were determined by the Stern-Volmer method. The rate is nearly constant at a diffusion-controlled limit in the region of E( 1/2 )(1) +), whereas log k(p) depends linearly on E( 1/2 )(1) in the region of E( 1/2 )(1) > 1.3 V, the slope of the correlation line being -αF/RT with α = 0.2. The potential at which the change in dependence of log k(p) on E( 1/2 )(1) occurs (1.3 V) is in accordance with the value of E( 1/2 )(Rho+(*)) (1.22 V) that has been obtained experimentally. Thus, the SET step is exothermic when E( 1/2 )(1) 1.3 V. The α-value (0.2) obtained in the endothermic region shows that the SET step from 1 to Rho+(*)is irreversible in this region. Trivalent phosphorus radical cation 1(·+) generated in the SET step undergoes an ionic reaction with water in the solvent rapidly enough to make the SET step irreversible. In contrast, the SET from amines 2 and alkoxybenzenes 3 to Rho+(*) is reversible when the SET step is endothermic, meaning that the radical cations 2(·+) and 3(·+) generated in the SET step undergo rapid 'back SET' in the ground state to regenerate 2 and 3.

REACTIONS OF TRIPHENYL PHOSPHITE WITH DI- AND TRIBROMOACETALDEHYDES

Sinyashina, T. N.,Mironov, V. F.,Ofitserov, E. N.,Konovalova, I. V.,Pudovik, A. N.

, p. 1483 - 1485 (1988)

-

Diphenyl Diselenide-Catalyzed Synthesis of Triaryl Phosphites and Triaryl Phosphates from White Phosphorus

Zhang, Yue,Cai, Ziman,Chi, Yangyang,Zeng, Xiangzhe,Chen, Shuanghui,Liu, Yan,Tang, Guo,Zhao, Yufen

, p. 5158 - 5163 (2021/07/20)

Industrially important triaryl phosphites, traditionally prepared from PCl3, have been synthesized by a diphenyl diselenide-catalyzed one-step procedure involving white phosphorus and phenols, which provides a halogen- and transition metal-free way to these compounds. Subsequent oxidation of triaryl phosphites produces triaryl phosphates and triaryl thiophosphates. Phosphorotrithioates are also prepared efficiently from aromatic thiols and aliphatic thiols.

Flash production of organophosphorus compounds in flow

Nagaki, Aiichiro,Tamaki, Takashi

supporting information, (2021/09/09)

Flow synthesis techniques have received a significant amount of attention due to their high productivity. However, when reaction condition is heterogeneous, it is usually difficult to adapt it to flow synthesis. Herein, by selecting appropriate reagents, the synthesis of phosphate esters, which is commonly heterogeneous, was made homogeneous, enabling synthesis in flow systems. In addition, reaction rate was accelerated compared to the batch system. It was demonstrated that not only can the high productivity of flow synthesis be achieved in flow, but also high productivity can be achieved by accelerating the reaction. Finally, we demonstrated the synthesis of the Akiyama-Terada catalyst, a chiral organocatalysts, in a short period.

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