936256-39-2Relevant academic research and scientific papers
Facile one-pot synthesis of 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3- sulfonic acid 1,1-dioxide
Siddiqui, Waseeq A.,Ahmad, Saeed,Khan, Islam Ullah,Siddiqui, Hamid Latif,Weaver, George W.
, p. 767 - 773 (2007)
We report a convenient synthesis of 4-hydroxy-2-methyl-(2H)-1,2- benzothiazine-3-sulfonic acid-1,1-dioxide (6a) prepared in a novel one-pot reaction. The synthesis involves two transformations starting from 2-methyl-2H-1,2-benzothiazin-4-(3H)-one 1,1-dioxide (7) with an overall yield better than that from the stepwise process, as well as the alternate procedure starting from saccharin (1). One-pot synthesis of an important intermediate, saccharin-N-methane sulfonic acid (4), is also described. Copyright Taylor & Francis Group, LLC.
