936368-52-4Relevant academic research and scientific papers
Transition Metal-Free Approach to Propynenitriles and 3-Chloropropenenitriles
Sharma, Pawan K.,Ram, Sita,Chandak, Navneet
, p. 894 - 899 (2016)
A transition metal-free, facile and efficient one-pot protocol for the synthesis of propynenitriles from readily available 3-chloropropenals is disclosed. The reaction conditions have also been optimized for the exclusive formation and isolation of 3-chloropropenenitriles which are important building blocks in general and are intermediates in the synthesis of propynenitriles. The hallmark of the methodology is the use of non-toxic reagents, milder, metal-free and economically benign reaction conditions avoiding a harsh dehydration step while achieving excellent yields.
Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions
Sharma, Pawan K.,Kumar, Rajiv,Ram, Sita,Chandak, Navneet
supporting information, p. 1847 - 1856 (2021/04/26)
A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.
3-halo-3-aryl acrylonitrile and preparation method thereof
-
Paragraph 0029; 0047-0049, (2018/05/16)
The invention discloses 3-halo-3-aryl acrylonitrile and a preparation method thereof. The method comprises the following steps: dissolving alkyne nitrile into a first substance comprising acetic acid,and adding alkaline metal halide salt to obtain a react
Direct synthesis of 3-halo-3-arylacrylonitriles from the addition of cyanoalkynes with alkaline metal halides
Guan, Zhipeng,Liu, Zhiwen,Shi, Wei,Chen, Hao
supporting information, p. 3602 - 3606 (2017/08/23)
An efficient synthesis of 3-halo-3-arylacrylonitrile is described from the direct addition between cyanoalkynes and inorganic alkaline metal halides such as LiCl, LiBr and KI in good to satisfactory yields. No transition metal is needed for the synthesis
Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
Romagnoli, Romeo,Baraldi, Pier Giovanni,Remusat, Vincent,Carrion, Maria Dora,Lopez Cara, Carlota,Preti, Delia,Fruttarolo, Francesca,Pavani, Maria Giovanna,Aghazadeh Tabrizi, Mojgan,Tolomeo, Manlio,Grimaudo, Stefania,Balzarini, Jan,Jordan, Mary Ann,Hamel, Ernest
, p. 6425 - 6428 (2007/10/03)
2-(3′,4′,5′-Trimethoxybenzoyl)-3-amino-5-aryl/heteroaryl thiophene derivatives were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. SARs were elucidated with various substitutions on
