93663-74-2

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-2-phenyl-, ethyl ester
• Synonyms: 3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-2-phenyl-, ethyl ester
• CAS NO: 93663-74-2
• Molecular Formula: C₁₈H₁₄ClNO₃
• Molecular Weight: 327.76
• Mol File: 93663-74-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 485.3°Cat760mmHg
• Flash Point: 247.3°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 1.42E-09mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-2-phenyl-, ethyl ester(93663-74-2)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-2-phenyl-, ethyl ester(93663-74-2)

Safety Data

• Hazardous Substances Data: 93663-74-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H14ClNO3/c1-2-23-18(22)15-16(11-6-4-3-5-7-11)20-14-9-8-12(19)10-13(14)17(15)21/h3-10H,2H2,1H3,(H,20,21)

Upstream product

• 916664-23-8 2-azido 5-chlorobenzaldehyde 
• 1479-22-7 ethyl 2-fluoro-3-oxo-3-phenylpropionate 

Downstream Products

• 17282-72-3 6-chloro-2-phenyl-quinolin-4-ol 

Relevant articles and documents

Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols

A [4 + 2] annulation involving cascade Knoevenagel, aza-Wittig and dehydrofluorination reactions is developed for the synthesis of substituted quinolin-4-ols including analogs bearing CF2H, CF3, and C2F5 groups. This simple and highly efficient method is also applicable for the synthesis of substituted quinolines. A number of reported biologically active compounds can be readily prepared by this one-pot synthesis. Green chemistry metrics analysis of the new reaction processes provided favorable results.