936699-55-7

Basic information

• Product Name: tert-butyl (R)-3-(4-chlorophenyl)-3-hydroxypropanoate
• Synonyms: tert-butyl (R)-3-(4-chlorophenyl)-3-hydroxypropanoate
• CAS NO: 936699-55-7
• Molecular Weight: 256.729
• Mol File: 936699-55-7.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-3-(4-chlorophenyl)-3-hydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-3-(4-chlorophenyl)-3-hydroxypropanoate(936699-55-7)
• EPA Substance Registry System: tert-butyl (R)-3-(4-chlorophenyl)-3-hydroxypropanoate(936699-55-7)

Safety Data

• Hazardous Substances Data: 936699-55-7(Hazardous Substances Data)

Upstream product

• 272459-41-3 tertbutyl-3-hydroxy-3-(4-chlorophenyl)-propionate 
• 108-24-7 acetic anhydride 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 51656-70-3 (2-tert-butoxy-2-oxoethyl)zinc(II) bromide 

Relevant articles and documents

D-Phg-L-Pro Dipeptide-derived prolinol ligands for highly enantioselective Reformatsky reactions

Optically pure N-aminoethyl prolinol derivatives 3a-c have been prepared from the dynamic kinetic resolution of N-(α-bromo-α-phenylacetyl) proline ester 1 in asymmetric nucleophilic substitution and subsequent reduction. The peptide-derived prolinols are

Access to optically pure β-hydroxy esters via non-enzymatic kinetic resolution by a planar-chiral DMAP catalyst

The development of new approaches to obtain optically pure β-hydroxy esters is an important area in synthetic organic chemistry since they are precursors of other high value compounds. Herein, the kinetic resolution of racemic β-hydroxy esters using a planar-chiral DMAP derivative catalyst is presented. Following this procedure, a range of aromatic β-hydroxy esters was obtained in excellent selectivities (up to s = 107) and high enantiomeric excess (up to 99% ee). Furthermore, the utility of the present method was demonstrated in the synthesis of (S)-3-hydroxy-N-methyl-3-phenylpropanamide, a key intermediate for bioactive molecules such as fluoxetine, tomoxetine or nisoxetine, in its enantiomerically pure form.

Asymmetric dehydration of β-hydroxy esters and application to the syntheses of flavane derivatives

Catalytic asymmetric dehydration of β-aryl or alkyl substituted β-hydroxy esters via kinetic resolution has been investigated. A brief survey of 10 different chiral ligands is conducted to examine the effects of chiral ligand structure on selectivity of t

Asymmetric dehydration of β-hydroxy esters via kinetic resolution

Catalytic asymmetric dehydration of β-hydroxy esters via kinetic resolution has been investigated. The kinetic resolution of rac-β-hydroxy esters in the presence of prolinol chiral ligand 2a and BrZnCH2CO2t-Bu can provide highly enan

Enantioselective reformatsky reaction induced by chiral β-amino alcohols

Reformatsky reagent derived from tert-butyl α-bromoacetate adds to carbonyl compounds in the presence of chiral amino alcohols leading to β-hydroxy tert-butyl eaters with good e.e. The enantioface differentiation depends on the reaction conditions and on