936724-71-9

Upstream product

• 99851-11-3 ethyl 2,2-diethyl-3-hydroxybutyrate 
• 98-59-9 p-toluenesulfonyl chloride 
• 2983-38-2 ethyl 2-ethylbutanoate 

Downstream Products

• 38477-05-3 2,2-diethylbut-3-enoic acid 
• 852102-05-7 N-{2-bromo-4-[(trifluoromethyl)oxy]phenyl}-2,2-diethylbut-3-enamide 
• 852102-04-6 N-[2-bromo-4-(trifluoromethyl)phenyl]-2,2-diethylbut-3-enamide 
• 852102-01-3 N-(2-bromo-4-methoxyphenyl)-2,2-diethylbut-3-enamide 
• 852102-03-5 N-(2-bromo-4-fluorophenyl)-2,2-diethylbut-3-enamide 
• 852102-02-4 N-(2-bromo-4-methylphenyl)-2,2-diethylbut-3-enamide 
• 852101-99-6 N-(2-bromophenyl)-2,2-diethylbut-3-enamide 

Relevant academic research and scientific papers

Synthesis of enantiomerically enriched α,α-disubstituted β,γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo(III)

Novel α,α-disubstituted epoxy esters were prepared in enantiopure form by hydrolytic kinetic resolution (HKR) of the corresponding racemic mixtures using chiral salenCo(III) as catalyst. The methodology provides a convenient route to enantioenriched β,γ-epoxy esters 2a, 2c and 2d.

Intramolecular cyclopropanation of unsaturated terminal epoxides and chlorohydrins

Lithium 2,2,6,6-tetramethylpiperidide (LTMP)-induced intramolecular cyclopropanation of unsaturated terminal epoxides provides an efficient and completely stereoselective entry to bicyclo[3.1.0]hexan-2-ols and bicyclo[4.1.0]heptan-2-ols. Further elaboration of C-5 and C-6 stannyl-substituted bicyclo[3.1.0]-hexan-2-ols via Sn-Li exchange/electrophile trapping or Stille coupling generates a range of substituted bicyclic cyclopropanes. An alternative straightforward cyclopropanation protocol using a catalytic amount of 2,2,6,6-tetramethylpiperidine (TMP) allows for a convenient (1 g-7.5 kg) synthesis of bicyclo[3.1.0]-hexan-2-ol and other bicyclic adducts. The synthetic utility of this chemistry has been demonstrated in a concise asymmetric synthesis of (+)-β-cuparenone. The related unsaturated chlorohydrins also undergo intramolecular cyclopropanation via in situ epoxide formation.

Regioselective synthesis of 3,3-diethyl-4-(methylene)-1-quinol-2-ones by an intramolecular microwave assisted heck reaction

A protocol for the intramolecular Heck cyclization to afford 3,3-diethyl-4-(methylene)-1-quinol-2-ones is described. We observed that the use of microwave irradiation increased the efficiency of the reaction. Several examples are presented which show the