2983-38-2

Basic information

• Product Name: 2-ETHYL-N-BUTYRIC ACID ETHYL ESTER
• Synonyms: 2-ethyl-butanoicaciethylester;Ethyl 2-ethylbutanoate;ETHYL 2-ETHYLBUTYRATE;2-ETHYL-N-BUTYRIC ACID ETHYL ESTER;2-ETHYLBUTYRIC ACID ETHYL ESTER;RARECHEM AL BI 0134;Butanoic acid, 2-ethyl-, ethyl ester;2-ETHYL-N-BUTYRIC ACID ETHYL ESTER 97+%
• CAS NO: 2983-38-2
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21
• EINECS: 221-044-9
• Product Categories: Organics
• Mol File: 2983-38-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 149-152°C
• Boiling Point: 152°C
• Flash Point: 39°C
• Appearance: /
• Density: 0,87 g/cm3
• Vapor Pressure: 2.91mmHg at 25°C
• Refractive Index: 1.4030 to 1.4050
• CAS DataBase Reference: 2-ETHYL-N-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHYL-N-BUTYRIC ACID ETHYL ESTER(2983-38-2)
• EPA Substance Registry System: 2-ETHYL-N-BUTYRIC ACID ETHYL ESTER(2983-38-2)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 3272
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 2983-38-2(Hazardous Substances Data)

Usage

Chemical Properties

Colorless clear liquid.

InChI:InChI=1/C8H16O2/c1-4-7(5-2)8(9)10-6-3/h7H,4-6H2,1-3H3

Upstream product

• 141-78-6 ethyl acetate 
• 141-52-6 sodium ethanolate 
• 77-25-8 diethyl diethylmalonate 
• 60-29-7 diethyl ether 
• 513-35-9 2-methyl-but-2-ene 
• 109-94-4 formic acid ethyl ester 
• 1619-56-3 ethyl 2-ethyl-2-cyanobutyrate 
• 7647-01-0 hydrogenchloride 
• 93504-83-7 2-(ethoxycarbonyl)-2-ethylbutanoic acid 
• 510-20-3 diethyl malonic acid 
• 65946-52-3 1-Ethoxy-1-trimethylsilyloxy-1-buten 
• 607-97-6 ethyl 2-ethyl-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 

Downstream Products

• 116773-05-8 ethyl 2-benzoyl-2-ethylbutanoate 
• 19398-78-8 3,4-diethyl-3-hexanol 
• 97-95-0 2-ethyl-1-butanol 
• 94759-73-6 2-ethyl-1,1-bis-(4-methoxy-phenyl)-but-1-ene 
• 813-58-1 triethylacetic acid 
• 88131-79-7 4-phenyl-2,2-diethylbutanopiperidide 
• 88131-81-1 N-(1-(α-hydroxybenzyl)ethyl)-N-ethyl-2,2-diethylbutanamide 
• 88132-02-9 C₁₉H₂₈⁽²⁾HNO 
• 88156-71-2 N,N-(2-(n-butyl)-4-phenylpentane-1,5-diyl)-2,2-diethylbutanamide 
• 88131-83-3 N,N-(2(e)-(α-hydroxybenzyl)-4-phenylpentane-1,5-diyl)-2,2-diethylbutanamide 
• 88131-83-3 α-(4-phenylpiperidin-2(a)-yl)benzyl 2,2-diethylbutanoate 
• 88131-83-3 α-(4-phenylpiperidin-2(a)-yl)benzyl 2,2-diethylbutanoate 
• 88131-94-6 2(a)-benzoyl-4-phenyl-2,2-diethylbutanopiperidide 
• 88131-93-5 2(e)-benzoyl-4-phenyl-2,2-diethylbutanopiperidide 

Relevant articles and documents

Preparation method of remdesivir intermediate 2-ethyl-1-butanol

The invention relates to a preparation method of a remdesivir intermediate 2-ethyl-1-butanol. The preparation method comprises a step of substitution reaction, namely a step of carrying out a substitution reaction on alkyl acetoacetate and halogenated ethane under an alkaline condition to obtain alkyl 2-ethyl-3-oxo-butyrate; a step of addition reduction, namely a step of carrying out an addition reduction reaction on the alkyl 2-ethyl-3-oxo-butyate to obtain alkyl 2-ethylbutyrate; a step of reduction, namely a step of subjecting the alkyl 2-ethylbutyrate to a reduction reaction to prepare 2-ethyl-1-butanol (I). According to the preparation method of the remdesivir intermediate 2-ethyl-1-butanol, the alkyl acetoacetate and halogenated ethane serve as main raw materials, the raw materials are simple and easy to obtain, the 2-ethyl-1-butanol (I) is prepared through substitution reaction, addition reduction and reduction reaction, the process is simple, economical and environmentally friendly, the product is convenient to obtain, and industrial production of remdesivir bulk drugs is facilitated.

Cyano diels-alder and cyano ene reactions. Applications in a formal [2 + 2 + 2] cycloaddition strategy for the synthesis of pyridines

Two metal-free, formal [2 + 2 + 2] cycloaddition strategies for the construction of polycyclic pyridine derivatives are described that proceed via pericyclic cascade mechanisms featuring the participation of unactivated cyano groups as enophile and dienophile cycloaddition partners.

Radical Reaction of Ketene Alkyl Trimethylsilyl Acetals with Divinyl Sulfone Promoted by Titanium(IV) Chloride

-