936832-73-4Relevant academic research and scientific papers
Asymmetric synthesis of α-chiral dihydrocinnamates by catalytic reductive aldol coupling and subsequent dehydroxylation
Hashimoto, Toru,Shiomi, Takushi,Ito, Jun-ichi,Nishiyama, Hisao
, p. 12883 - 12887 (2007)
Optically active dihydrocinnamate derivatives bearing the chiral carbon center at α-position were synthesized by Rh(Phebox)-catalyzed asymmetric reductive aldol coupling reaction with substituted cinnamates and benzaldehyde derivatives and subsequent dehydroxylation reaction.
Intermolecular asymmetric reductive aldol reaction of ketones as acceptors promoted by chiral Rh(Phebox) catalyst
Shiomi, Takushi,Nishiyama, Hisao
, p. 1651 - 1654 (2008/02/02)
The conjugate reduction of cinnamates with hydrosilane and chiral Rh(Phebox-ip) catalyst in the presence of excess acetone is shown to provide the corresponding intermolecular reductive aldol product in extremely high enantioselectivity (up to 98%). Several cinnamates and crotonate substrates and several ketone acceptors were also examined.
