93712-59-5Relevant academic research and scientific papers
Enantioselective Synthesis of Fused Polycyclic Tropanes via Dearomative [3 + 2] Cycloaddition Reactions of 2-Nitrobenzofurans
Wang, Zhen,Wang, Dong-Chao,Xie, Ming-Sheng,Qu, Gui-Rong,Guo, Hai-Ming
, p. 164 - 167 (2020)
A straight synthetic approach to fused polycyclic tropane scaffold formation through an asymmetric dearomatization cycloaddition process of 2-nitrobenzofurans with cyclic azomethine ylides was successfully developed. In the presence of a chiral copper com
Synthesis and evaluation of β-carboline derivatives as inhibitors of human immunodeficiency virus
Brahmbhatt, Keyur G.,Ahmed, Nafees,Sabde, Sudeep,Mitra, Debashis,Singh, Inder Pal,Bhutani, Kamlesh K.
scheme or table, p. 4416 - 4419 (2010/09/18)
A series of β-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL4.3 virus. 1-Formyl-β-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC50 = 2.9 μM.
Aromatization and chemoselective alkylation of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and its derivatives
Brahmbhatt, Keyur G.,Ahmed, Nafees,Singh, Inder P.,Bhutani, Kamlesh K.
scheme or table, p. 5501 - 5504 (2010/01/03)
Unprecedented aromatization was observed during N-alkylation reactions of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid methyl ester, giving rise to 9-alkyl-1-methyl-β-carboline-3-carboxylic acid methyl esters. Inverse addition of base during a simil
