937189-04-3

Basic information

• Product Name: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate
• Synonyms: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate
• CAS NO: 937189-04-3
• Molecular Weight: 267.306
• Mol File: 937189-04-3.mol

Chemical Properties

• CAS DataBase Reference: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(937189-04-3)
• EPA Substance Registry System: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(937189-04-3)

Safety Data

• Hazardous Substances Data: 937189-04-3(Hazardous Substances Data)

Upstream product

• 16156-58-4 prop-2-yn-1-ol methanesulfonate 
• 104-87-0 4-methyl-benzaldehyde 
• 124-63-0 methanesulfonyl chloride 
• 3235-02-7 p-methylbenzaldehyde oxime 

Downstream Products

• 1240190-05-9 N-[(3-p-methylphenylisoxazol-5-yl)-methyl]-(R)-2-tert-butoxycarbonylmethylhexanamide 
• 1240190-13-9 N-[(3-p-methylphenylisoxazol-5-yl)-methyl]-(R)-2-methoxycarbonylmethylhexanamide 
• 937189-02-1 C₁₁H₁₀N₄O 
• 1240190-19-5 (R)-2-butyl-N₄-hydroxy-N₁-[(3-p-methylphenylisoxazol-5-yl)-methyl]succinamide 
• 934333-69-4 5-aminomethyl-3-p-methylphenylisoxazole 

Relevant articles and documents

Green one-pot four-component synthesis of 3,5-disubstituted isoxazoles- sulfonates and sulfonamides using a combination of NaDCC as metal-free catalyst and ultrasonic activation in water

A simple and green one-pot reaction has been proposed for the synthesis of novel 3,5-disubstituted isoxazole-sulfonates and -sulfonamides (5a-j) in water under ultrasound irradiation. The methodology is based on the use of safe and environmentally friendly reagents and allows, via in-situ 1,3-dipolar cycloaddition, an easy access to functionalized heterocycles with the creation of four new bonds (S[sbnd]O, C[sbnd]N, C[sbnd]O and C[sbnd]C). Comparison studies using classical magnetic stirring and ultrasound irradiation clearly showed that sonication promoted clean transformation, high yields (72–89%) and faster reactions (20–28 min). All the synthesized compounds were fully characterized by MS-ES, 1H NMR, 13C NMR spectroscopy and HPLC analysis.

Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings

Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.