937251-28-0Relevant articles and documents
The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents
Murphy, Sean T.,Case, Heather L.,Ellsworth, Edmund,Hagen, Susan,Huband, Michael,Joannides, Themis,Limberakis, Chris,Marotti, Keith R.,Ottolini, Amy M.,Rauckhorst, Mark,Starr, Jeremy,Stier, Michael,Taylor, Clarke,Zhu, Tong,Blaser, Adrian,Denny, William A.,Lu, Guo-Liang,Smaill, Jeff B.,Rivault, Freddy
, p. 2150 - 2155 (2008/02/02)
Several novel series of nitrile-containing fluoroquinolones with weakly basic amines are reported which have reduced potential for hERG (human ether-a-go-go gene) channel inhibition as measured by the dofetilide assay. The new fluoroquinolones are potent
