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315718-05-9

1-Cbz-3-hydroxymethylpyrrolidine is a chemical compound that is widely used in scientific research and pharmaceutical manufacturing. It is an N-protected alpha-amino acid derivative, featuring a pyrrolidine ring in its structure. The "Cbz" in its name denotes the carboxybenzyl protective group, which is incorporated to shield certain functional groups during chemical reactions. 1-Cbz-3-hydroxymethylpyrrolidine is frequently employed as a building block or intermediate in the synthesis of more complex molecules.

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  • 315718-05-9 Structure

  • Basic information

    1. Product Name: 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE
    2. Synonyms: 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE;3-HYDROXYMETHYL-1-CBZ-PYRROLIDINE;1-CBZ-DL-BETA-PROLINOL;3-Hydroxymethylpyrrolidine-1-carboxylic acid benzyl ester;benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate;1-Cbz-3-hydroxymethylpyrrolidine ada@tuskwei.com;1-Cbz-3-hydroxymethylpyrrolidine ada@tuskwei.com whatsapp
    3. CAS NO:315718-05-9
    4. Molecular Formula: C13H17NO3
    5. Molecular Weight: 235.28
    6. EINECS: N/A
    7. Product Categories: pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;1-Cbz-3-hydroxymethylpyrrolidine ada@tuskwei.com;1-Cbz-3-hydroxymethylpyrrolidine ada@tuskwei.com whatsapp;8618031153937
    8. Mol File: 315718-05-9.mol
    9. Article Data: 10

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 382 °C at 760 mmHg
    3. Flash Point: 184.8 °C
    4. Appearance: /
    5. Density: 1.196 g/cm3
    6. Vapor Pressure: 1.62E-06mmHg at 25°C
    7. Refractive Index: 1.56
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 14.93±0.10(Predicted)
    11. CAS DataBase Reference: 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(315718-05-9)
    13. EPA Substance Registry System: 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(315718-05-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 315718-05-9(Hazardous Substances Data)

315718-05-9 Usage

Uses

Used in Pharmaceutical Manufacturing:
1-Cbz-3-hydroxymethylpyrrolidine is used as a building block for the synthesis of complex pharmaceutical compounds. Its carboxybenzyl protective group allows for controlled reactions, facilitating the creation of a variety of drug molecules.
Used in Scientific Research:
1-Cbz-3-hydroxymethylpyrrolidine is used as an intermediate in the synthesis of various research compounds. Its presence in the structure of these molecules can provide insights into their properties and potential applications in different fields.
Used in Organic Chemistry:
1-Cbz-3-hydroxymethylpyrrolidine is used as a reagent in organic chemistry, where its protective group and pyrrolidine ring can be manipulated to produce a range of organic compounds for further study and application.

Check Digit Verification of cas no

The CAS Registry Mumber 315718-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,5,7,1 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 315718-05:
(8*3)+(7*1)+(6*5)+(5*7)+(4*1)+(3*8)+(2*0)+(1*5)=129
129 % 10 = 9
So 315718-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO3/c15-9-12-6-7-14(8-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2

315718-05-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name benzyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:315718-05-9 SDS

315718-05-9Relevant articles and documents

THIENO (2,3 - C) PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS

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Paragraph 0446, (2014/12/09)

The present invention provides compounds of formula (I): wherein A, R1, R2, R3 IX, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.

THIENO [2, 3 - C] PYRAZOLES FOR USE AS POTASSIUM CHANNEL INHIBITORS

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Page/Page column 70, (2013/06/05)

The present invention provides compounds of formula (I): wherein A, R1, R2, R3IX, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.

Concise synthesis of bicyclic aminals by way of catalytic intramolecular C-H amination and evaluation of their reactivity as iminium precursors

Rodriguez-Lucena, David,Morin, Marie S.T.,Compain, Philippe

, p. 155 - 162 (2012/04/04)

The concise synthesis of fused bicyclic aminals by way of intramolecular rhodium-catalyzed C-H amination is reported as well as the evaluation of their reactivity as iminium precursors. In contrast to the well-studied N,O-acetal systems, the aminals synthesized were found to be particularly stable under reaction conditions used for nucleophilic addition.

A library of conformationally restricted saturated heterocyclic sulfonyl chlorides

Zhersh, Sergey,Buryanov, Volodymyr V.,Karpenko, Oleksandr V.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.

scheme or table, p. 3669 - 3674 (2011/12/16)

An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides

5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE-DERIVATIVES AND THEIR USES AS ANTIBACTERIALS

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Page/Page column 15, (2009/10/06)

The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; Rsup

Disubstituted pyrimidines as Lck inhibitors

Hunt, Julianne A.,Beresis, Richard T.,Goulet, Joung L.,Holmes, Mark A.,Hong, Xinfang J.,Kovacs, Ernest,Mills, Sander G.,Ruzek, Rowena D.,Wong, Frederick,Hermes, Jeffrey D.,Park, Young-Whan,Salowe, Scott P.,Sonatore, Lisa M.,Wu, Lin,Woods, Andrea,Zaller, Dennis M.,Sinclair, Peter J.

supporting information; experimental part, p. 5440 - 5443 (2010/04/26)

We have developed a family of 4-benzimidazolyl-N-piperazinethyl-pyrimidin-2-amines that are subnanomolar inhibitors of Lck. A subset of these Lck inhibitors, with heterocyclic substituents at the benzimidazole C5, are also low-nanomolar inhibitors of cell

5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES

-

Page/Page column 37, (2008/12/05)

The invention relates to novel chimeric antibiotics of formula (I) wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; Rs

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents

Murphy, Sean T.,Case, Heather L.,Ellsworth, Edmund,Hagen, Susan,Huband, Michael,Joannides, Themis,Limberakis, Chris,Marotti, Keith R.,Ottolini, Amy M.,Rauckhorst, Mark,Starr, Jeremy,Stier, Michael,Taylor, Clarke,Zhu, Tong,Blaser, Adrian,Denny, William A.,Lu, Guo-Liang,Smaill, Jeff B.,Rivault, Freddy

, p. 2150 - 2155 (2008/02/02)

Several novel series of nitrile-containing fluoroquinolones with weakly basic amines are reported which have reduced potential for hERG (human ether-a-go-go gene) channel inhibition as measured by the dofetilide assay. The new fluoroquinolones are potent

QUINOLONE ANTIBACTERIAL AGENTS

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Page/Page column 109-110, (2010/02/11)

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.

QUINOLONE ANTIBACTERIAL AGENTS

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Page/Page column 136-137, (2010/02/11)

Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

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