93744-25-3

Upstream product

• 611-20-1 salicylonitrile 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 

Downstream Products

• 131769-23-8 (R)-(+)-1-<2-<3-(2-cyanophenoxy)-2-hydroxypropyl>aminoethyl>-2,4-dioxo-3-phenyl-1H,3H-imidazolidine 
• 93744-17-3 (R)-(-)-3-(2-cyanophenoxy)-1,2-epoxypropane 
• 93744-26-4 (S)-(+)-2-acetyloxy-1-bromo-3-(2-cyanophenoxy)propane 

Relevant academic research and scientific papers

A FACILE ENANTIOSELECTIVE SYNTHESIS OF AN ARYLOXYPROPANOLAMINE β-BLOCKER THROUGH A TWO-STEP CONVERSION OF 1,3-DIOXOLANES INTO EPOXIDES

A facile and convenient synthesis of the two enantiomers of P-0160, an aryloxypropanolamine β-blocker, is presented.The key step is the reaction of a chiral isopropylideneglycerol derivative with hydrobromic acid in acetic acid to afford a 2-acetoxy-1-bro

Aryloxypropanolamine derivatives, pharmaceutical compositions and adrenegic thereof

Compounds having general formula I STR1 wherein R1 is hydrogen, lower alkyl, lower alkoxy, alkyl enoxy, halogen, cyano, carboxyamido or ureido group optionally separated from the phenyl ring by a methylene or ethylene bridge; R2 is hydrogen, halogen, lower alkyl or alkoxy; R3 is hydrogen, halogen, lower alkyl, lower alkoxy or R2 and R3, taken together, are a methylendioxy group; R4 is hydrogen or lower alkyl, endowed with remarkable cardioselective β-adrenolytic properties, are described. The process for their preparation and pharmaceutical compositions containing them are also described.