937678-86-9Relevant articles and documents
BIARYL OXYACETIC ACID COMPOUNDS
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Page/Page column 62-63, (2011/02/24)
Some embodiments of the present invention include novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. Some compounds provided include those of the general formula (I), and compounds of general formula (Ia).
Synthesis of 5-substituted benzyl-2,4-diamino pyrimidine derivatives as c-Fms kinase inhibitors
Xu, Li Bao,Sun, Wei,Liu, Hong Ying,Wang, Li Li,Xiao, Jun Hai,Yang, Xiao Hong,Li, Song
scheme or table, p. 1318 - 1321 (2011/10/09)
A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method. The results showed that compound 15,5-[3-methoxy-4-(pyridine-3-yl)benzyl]-2,4-diamino pyrimidine, had an IC50 of 1.45μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice (NFS-60), which was similar with GW2580, a selective inhibitor of c-Fms kinase.