1256644-98-0

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 937678-86-9 4-(4-methoxybenzyloxy)-3-bromobenzaldehyde 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 1256645-18-7 C₂₄H₂₁BrN₂O₂ 
• 50-01-1 guanidine hydrochloride 

Relevant academic research and scientific papers

Synthesis of 5-substituted benzyl-2,4-diamino pyrimidine derivatives as c-Fms kinase inhibitors

A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method. The results showed that compound 15,5-[3-methoxy-4-(pyridine-3-yl)benzyl]-2,4-diamino pyrimidine, had an IC50 of 1.45μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice (NFS-60), which was similar with GW2580, a selective inhibitor of c-Fms kinase.