93793-83-0

Basic information

• Product Name: Roxatidine acetate hydrochloride
• Synonyms: 2-acetoxy-n-[3-[3-(1-piperidinomethylphenoxy]propyl]acetamide hydrochloride;2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-acetamidmonoh;2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamidehydrochloride;2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)-acetamidacetate(ester;2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamideacetate(ester);aceroxatidinehydrochloride;acetamide,2-hydroxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)-,acetate,;tzu0460
• CAS NO: 93793-83-0
• Molecular Formula: C₁₉H₂₈N₂O₄*ClH
• Molecular Weight: 384.89756
• EINECS: 1308068-626-2
• Product Categories: Miscellaneous Biochemicals;Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;MEFOXIN;Other APIs
• Mol File: 93793-83-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 145-146°
• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.7 °C
• Appearance: /
• Vapor Pressure: 1.29E-11mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Merck: 14,8274
• CAS DataBase Reference: Roxatidine acetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Roxatidine acetate hydrochloride(93793-83-0)
• EPA Substance Registry System: Roxatidine acetate hydrochloride(93793-83-0)

Safety Data

• RTECS: AC3855000
• Hazardous Substances Data: 93793-83-0(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 93793-83-0 differently. You can refer to the following data:
1. Roxatidine acetate hydrochloride is an H2 antagonist, differing considerably in structure from other marketed agents(cimetidine, ranitidine and famotidine) in this category. It is useful in the treatment of gastric, duodenal and anastomotic ulcers, Zollinger-Ellison syndrome and peptic esophagitis.
2. Roxatidine acetate is a competitive histamine H2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine. By inhibiting the binding of histamine to H2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.

Chemical Properties

White Solid

Originator

Teikoku Hormone (Japan)

Uses

A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.

Brand name

ALTAT

InChI:InChI=1/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H

Upstream product

• 15504-60-6 1-(3-hydroxybenzoyl)piperidine 
• 99-06-9 3-Carboxyphenol 
• 108-24-7 acetic anhydride 
• 110925-92-3 2C₁₇H₂₆N₂O₃*C₂H₂O₄ 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 13831-31-7 Acetoxyacetyl chloride 
• 108-39-4 3-methyl-phenol 
• 26646-51-5 3-(m-tolyloxy)propylamine 
• 110-89-4 piperidine 
• 97900-88-4 C₁₇H₂₆N₂O₃*(x)ClH 
• 100-83-4 meta-hydroxybenzaldehyde 
• 73279-04-6 3-[1-piperidinylmethyl]phenol 
• 127-08-2 potassium acetate 
• 108441-34-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>chloroacetamide 

Downstream Products

• 1338084-91-5 C₁₉H₂₈N₂O₄*C₄₂H₇₀O₃₅ 

Relevant articles and documents

A preparation method for rosacea acetate hydrochloride

The present invention relates to the field of pharmaceutical preparation technology, in particular to a method for preparing rosatidine acetate hydrochloride. The present invention adopts m-hydroxybenzoic acid as a starting material, a wide range of sources, inexpensive, and it can be prepared by oxidation of m-hydroxytoluene, without involving a toxicity warning structure and nitrosamine impurities; at the same time, in this preparation process only involves a genotoxic warning structure substance, reducing the risk of medication of subsequent drugs.

Preparation method of roxatidine acetate hydrochloride

The invention relates to a preparation method of roxatidine acetate hydrochloride. The preparation method comprises the following steps: step 1, dissolving m-cresol and 3-chloropropylamine hydrochloride into a reaction solvent according to a certain ratio, carrying out a reaction in the presence of an alkali, extracting after the reaction, and concentrating after simple purification to obtain an intermediate 1; 2, dissolving the intermediate 1 and an alkali in a reaction solvent according to a certain ratio, adding acetoxyacetyl chloride in a dropwise manner at a low temperature, and extracting and concentrating after the reaction of the intermediate 1 is finished to obtain an intermediate 2; 3, carrying out a bromination reaction on the intermediate 2 and N-bromosuccinimide, and directlycarrying out water washing extraction to obtain an intermediate 3; 4, carrying out a reaction on the intermediate 3 and excessive piperidine in a solvent, concentrating, extracting with dichloromethane, drying, and further purifying with acetic anhydride to obtain roxatidine acetate; 5, dissolving the intermediate 3 in acetone, adding hydrochloric acid in a dropwise manner to form a salt, filtering, and drying; and 6, mixing with absolute ethyl alcohol, filtering, carrying out cooling crystallization, and drying to obtain the roxatidine acetate hydrochloride.

Preparation method of roxatidine acetate hydrochloride

The invention discloses a preparation method of roxatidine acetate hydrochloride. The preparation method is characterized by adopting m-hydroxybenzaldehyde and piperidine as raw materials for carrying out chemical synthesis under the conditions of microwave radiation and high frequency ultrasonic wave, so that the product yield is improved, the reaction time is shortened, the cost is reduced, the product purity is improved, the total impurities are reduced, and an ideal effect is achieved.