938-39-6Relevant articles and documents
Coumarin derivative and analogue, preparation method and application thereof
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Paragraph 0147-0150, (2021/03/31)
The invention relates to a coumarin derivative and analogue, a preparation method and application thereof, belongs to the field of chemical medicines, and provides a compound shown as a formula I or apharmaceutically acceptable salt thereof, and a preparation method and application of the compound. According to the invention, biological experiments show that the compound has a strong in-vitro anti-fibrosis effect, can obviously reduce deposition of intercellular collagenous fibers on TGF-beta induced NRK-49F cells, and has inhibition on migration of HUVEC cells; and the compound with the structure has a certain curative effect on carbon tetrachloride induced hepatic fibrosis and bleomycin induced pulmonary fibrosis mouse models, is relatively low in toxicity, and provides a new choice forclinical treatment of tissue fibrosis diseases including hepatic fibrosis, pulmonary fibrosis and renal fibrosis.
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
Zwergel, Clemens,Czepukojc, Brigitte,Evain-Bana, Emilie,Xu, Zhanjie,Stazi, Giulia,Mori, Mattia,Patsilinakos, Alexandros,Mai, Antonello,Botta, Bruno,Ragno, Rino,Bagrel, Denise,Kirsch, Gilbert,Meiser, Peter,Jacob, Claus,Montenarh, Mathias,Valente, Sergio
, p. 316 - 333 (2017/04/21)
Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle processes and are found overexpressed in a large panel of cancer typology. Here, we describe the development of two novel quinone-polycycle series of CDC25A and C inhi
Regioselective Alkoxydehalogenation of 2,4-Dihalogenoquinolines and a Reinvestigation of the Bromination of 2-Methoxyquinoline
Osborne, Alan G.,Miller, Luke A. D.
, p. 181 - 184 (2007/10/02)
Regioselective alkoxydehalogenation of 2,4-dichloro- and 2,4-dibromo-quinoline with solid sodium alkoxide in toluene gives the 2-alkoxy-4-halogenoquinolines 7-10, identified by 1H and 13C NMR spectroscopy.Bromination of 2-methoxyquinoline occurs at the 6- and 8-positions and does not give the 4-bromo derivative as originally reported.