93832-29-2Relevant academic research and scientific papers
Synthesis of Functionalized Hydroxyphthalides and Their Conversion to 3-Cyano-1(3H)-isobenzofuranones. The Diels-Alder Reaction of Methyl 4,4-Diethoxybutynoate and Cyclohexadienes
Freskos, John N.,Morrow, Gary W.,Swenton, John S.
, p. 805 - 810 (2007/10/02)
Several methods have been used in the preparation of functionalized hydroxyphthalides.Metalation of N,N-diethyl-3-methoxybenzamide, followed by reaction with dimethylformamide and hydrolysis, furnished 3-hydroxy-4-methoxy-1(3H)-isobenzofuranone in 52perce
A Convenient Synthesis of Hydroxyphthalides
Freskos, John,Cynkowski, Tadeusz,Swenton, John S.
, p. 819 - 820 (2007/10/02)
The Diels-Alder reaction of in situ generated cyclohexa-1,3-dienes with methyl 4,4-diethoxybut-2-ynoate (1) followed by reverse Diels-Alder and hydrolysis affords substituted hydroxyphthalides in good yield.
