938454-04-7

Basic information

• Product Name: (S)-2-[(S)-1-(4-fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one
• Synonyms: (S)-2-[(S)-1-(4-fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one
• CAS NO: 938454-04-7
• Molecular Weight: 310.392
• Mol File: 938454-04-7.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-[(S)-1-(4-fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(S)-1-(4-fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one(938454-04-7)
• EPA Substance Registry System: (S)-2-[(S)-1-(4-fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one(938454-04-7)

Safety Data

• Hazardous Substances Data: 938454-04-7(Hazardous Substances Data)

Upstream product

• 870709-87-8 2-[(S)-1-(4-fluorophenyl)ethylamino]-5-methylthiazol-4(5H)-one 
• 67-64-1 acetone 

Relevant articles and documents

Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11β-hydroxysteroid dehydrogenase type 1 inhibitors: Reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model

A series of compounds containing the 2-amino-1,3-thiazol-4(5H)-one core were found to be potent inhibitors of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). One of our lead compounds from this series activated the human nuclear xenobiotic