939047-03-7

Basic information

• Product Name: methyl α-(p-nitrophenyl)-α-isocyanoacetate
• Synonyms: methyl α-(p-nitrophenyl)-α-isocyanoacetate
• CAS NO: 939047-03-7
• Molecular Weight: 220.185
• Mol File: 939047-03-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl α-(p-nitrophenyl)-α-isocyanoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl α-(p-nitrophenyl)-α-isocyanoacetate(939047-03-7)
• EPA Substance Registry System: methyl α-(p-nitrophenyl)-α-isocyanoacetate(939047-03-7)

Safety Data

• Hazardous Substances Data: 939047-03-7(Hazardous Substances Data)

Upstream product

• 39687-95-1 isocyanoacetic acid methyl ester 
• 350-46-9 4-Fluoronitrobenzene 
• 5407-25-0 2-amino-2-(4-nitrophenyl)acetic acid 

Downstream Products

• 939047-12-8 N-butyl-1-(5-methoxy-4-(4-nitrophenyl)oxazol-2-yl)heptan-1-amine 
• 1268386-16-8 C₁₉H₁₈N₂O₅ 
• 1268386-18-0 C₂₂H₂₂N₂O₅ 
• 1268386-17-9 C₁₄H₁₆N₂O₅ 

Relevant articles and documents

Modulating the reactivity of α-isocyanoacetates: Multicomponent synthesis of 5-methoxyoxazoles and furopyrrolones

A simple approach to complexity: The reactivity pattern of α-isocyanoacetates can be tuned by modulating the acidity of the α C-H bond(s) against the nucleophilicity of the conjugate base. The unique reactivity of the α-(p-nitrophenyl)-α-isocyanoacetate 1 was exploited in a three-component synthesis of 5-methoxyoxazoles 2 and four-component synthesis of furopyrrolones 3. R1,R2,R 3 = alkyl, aryl, benzyl; R4 = aryl. (Chemical Equation Presented).

Exploiting the divergent reactivity of α-isocyanoacetate: Multicomponent synthesis of 5-alkoxyoxazoles and related heterocycles

A novel multicomponent synthesis of 5-alkoxyoxazoles, based on a new reactivity profile of α-isocyanoacetates, is described. Thus, simply heating a solution of amine, aldehyde, and α-(EWG-phenyl)-α- isocyanoacetate or α-(4-pyridyl)-α-isocyanoacetate (EWG=