93922-63-5

Upstream product

• 108-94-1 cyclohexanone 
• 68631-50-5 Diethyl L-tartrate 
• 87-91-2 diethyl (2R,3R)-tartrate 

Downstream Products

• 1453873-46-5 C₄₉H₅₅N₃O₂ 
• 1453873-66-9 C₃₅H₃₄N₂O₂S 
• 1453873-65-8 C₃₄H₃₆N₂O₂ 
• 1453873-64-7 C₃₄H₃₂N₆O₂ 
• 114026-76-5 (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane 
• 1609262-63-6 C₄₉H₅₅N₃O₂*ClH 

Relevant academic research and scientific papers

Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael addition of 3-substituted oxindoles to nitroolefins

The Michael addition of 3-substituted oxindoles to nitroolefins was catalyzed by a novel tartrate-derived guanidine in high yield with excellent diastereo- and enantioselectivity. This method showed an extraordinarily broad substrate scope in terms of both reaction partners. the Partner Organisations 2014.

PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS

Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein

Stereoselective total synthesis of synparvolide B and epi-synparvolide A

Stereoselective total synthesis of synparvolide B and epi-synparvolide A has been achieved following a convergent approach. Noyori asymmetric Transfer Hydrogenation of ketone and Wadsworth-Emmons olefination reaction are the key steps involved.

Kinetically controlled ring-closing metathesis: Synthesis of a potential scaffold for 12-membered salicylic macrolides

For the synthesis of a 12-membered salicylic macrolide scaffold, ringclosing metathesis (RCM) of a ω-diene compound was planned. The stereochemical outcome of the RCM reaction changed depending on the type of Ru catalyst that was used; a "first-generation

Synthesis of 1-Deoxy-D-galactohomonojirimycin via Enantiomerically Pure Allenylstannanes

1-Deoxy-D-galactohomonojirimycin was synthesized in seven steps from optically pure allenylstannane 4 and L-lactate-derived aldehyde 5 in 48% overall yield. The key step was the Lewis acid catalyzed reaction of 4 and 5 to give the syn-amino alcohol in exc

Development of new asymmetric two-center catalysts in phase-transfer reactions

A new asymmetric two-center phase-transfer catalyst was designed and a catalyst library containing more than 40 new two-center catalysts was constructed. The catalysts were applied in phase-transfer alkylations and Michael additions to afford the correspo

Facile approach towards the synthesis of homochiral functionalised alcohols from 4-O-[(tert)-butyldimethylsilyl]2,3-O-cyclohexylidene-L-threose of (L)-(+)-tartaric acid origin

(L)-(+)-Diethyl tartarate 2 has been transformed into the aldehyde 6. Grignard additions to 6 take place with moderate diastereoselectivity giving predominant formation of the anti products 8a-e. However, in each case the diastercoalcohols are easily sepa

SYNTHETIC STUDIES TOWARDS (-)-QUASSIMARIN: AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE BCE RING SYSTEM

A novel and a chiral approach to the synthesis of BCE ring system of (-)-quassimarin is described which involves an intramolecular Diels-Alder reaction of the trienic precursor (18) as a key step.The key dihydrofuranone (17) was prepared from L-(+)-diethyl tartrate via 14 step sequence.The quaternary carbon centre in (17) was stereoselectively constructed by magnesium chelation controlled addition of α-lithio-α-methoxyallene to α,β-dialkoxy ketone.Thermolysis of the triene (18) and subsequent hydrolysis provided two tricyclic cycloadducts (19) and (20), both structures were characterized spectroscopically as the corresponding acetates (21) and (22).Particularly, the major adduct (21) was established by the X-ray crystallographic analysis.

Synthesis of cis- and trans-1,3,5,7-Tetranitro-1,3,5,7-tetraazadecalin

The synthesis and preliminary characterization of two new polynitramine compounds, cis- and trans-1,3,5,7-tetranitro-1,3,5,7-tetraazadecalin (1 and 2), is described.Also isolated and partially characterized were two byproducts of the synthesis of 1 and 2, (R*,R*)-1,1',3,3'-tetranitro-4,4'-biimidazolidine (3) and (R*,S)-1,1',3,3'-tetranitro-4,4'-biimidazolidine (4).