93969-49-4

Basic information

• Product Name: 2H-Azepin-2-one, 3-(3,4-dihydro-6-methyl-4-oxo-2-phenyl-2H-1,3-oxazin-2-yl)hexahydro-
• CAS NO: 93969-49-4
• Molecular Formula: C17H20N2O3
• Molecular Weight: 300.357
• Mol File: 93969-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Azepin-2-one, 3-(3,4-dihydro-6-methyl-4-oxo-2-phenyl-2H-1,3-oxazin-2-yl)hexahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Azepin-2-one, 3-(3,4-dihydro-6-methyl-4-oxo-2-phenyl-2H-1,3-oxazin-2-yl)hexahydro-(93969-49-4)
• EPA Substance Registry System: 2H-Azepin-2-one, 3-(3,4-dihydro-6-methyl-4-oxo-2-phenyl-2H-1,3-oxazin-2-yl)hexahydro-(93969-49-4)

Safety Data

• Hazardous Substances Data: 93969-49-4(Hazardous Substances Data)

Upstream product

• 16673-80-6 6-methyl-2-phenyl-4H-1,3-oxazin-4-one 
• 3553-94-4 1-trimethylsilanyl-azepan-2-one 

Downstream Products

• 22585-46-2 3-benzoyl-ε-caprolactam 

Relevant articles and documents

1,3-Oxazines and Related Compounds. VIII. Reaction of 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one with Lactams and Their Derivatives

6-Methyl-2-phenyl-4H-1,3-oxazin-4-one (1) underwent initial attack of the anions of lactams (2), such as ε-capro- (2a), δ-valero- (2b), and γ-butyro-lactams (2c), at the 4-position of the ring to give the corresponding α-substituted lactams (3a-c).Reaction of 1 with N-trimethylsilyl derivatives (6a-c) of 2 in the presence of lithium diisopropylamide afforded the 2,3-dihydro-4H-1,3-oxazin-4-one derivatives (7a-c), respectively.Similar treatment of 1 with O-methyl derivatives (9a-c) of 2 yielded the corresponding bicyclic heterocycles (10a-c).Keywords: 4H-1,3-oxazin-4-one; 2,3-dihydro-4H-1,3-oxazin-4-one; lithium diisopropylamide; butyllithium; ring transformation; lactam; lactim ether; N-trimethylsilyllactam.