22585-46-2

Upstream product

• 105-60-2 caprolactam 
• 93-89-0 benzoic acid ethyl ester 
• 93969-49-4 3-(6-Methyl-4-oxo-2-phenyl-3,4-dihydro-2H-[1,3]oxazin-2-yl)-azepan-2-one 
• 16673-80-6 6-methyl-2-phenyl-4H-1,3-oxazin-4-one 
• 948314-52-1 acetyl caprolactam 
• 3553-94-4 1-trimethylsilanyl-azepan-2-one 
• 727418-77-1 3-benzoyl-1-vinyl-azepan-2-one 

Relevant academic research and scientific papers

Synthesis and the keto-enol equilibrium of 2-acyl lactams

Condensation of N-substituted lactams with carboxylic acid esters was studied. A wide range of substituted 2-acyl lactams with different ring sizes were synthesized. The structure of 2-acyl lactams (primarily, the ring size) was found to influence the ket

Process for the acylation of lactams

High quality acyl lactam imides are prepared by reacting an acyl lactam of the formula STR1 where 5 carbon atoms and an acylating acid of the formula R'CO2 H or by reacting a lactam, an anhydride of the formula (RCO)2 O where R is 1

1,3-Oxazines and Related Compounds. VIII. Reaction of 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one with Lactams and Their Derivatives

6-Methyl-2-phenyl-4H-1,3-oxazin-4-one (1) underwent initial attack of the anions of lactams (2), such as ε-capro- (2a), δ-valero- (2b), and γ-butyro-lactams (2c), at the 4-position of the ring to give the corresponding α-substituted lactams (3a-c).Reaction of 1 with N-trimethylsilyl derivatives (6a-c) of 2 in the presence of lithium diisopropylamide afforded the 2,3-dihydro-4H-1,3-oxazin-4-one derivatives (7a-c), respectively.Similar treatment of 1 with O-methyl derivatives (9a-c) of 2 yielded the corresponding bicyclic heterocycles (10a-c).Keywords: 4H-1,3-oxazin-4-one; 2,3-dihydro-4H-1,3-oxazin-4-one; lithium diisopropylamide; butyllithium; ring transformation; lactam; lactim ether; N-trimethylsilyllactam.