939759-05-4 Usage
Uses
Used in Pharmaceutical Industry:
8-Chloro-3,4-dihydro-2H-benzo[1,4]oxazine is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities and unique structural properties. It aids in the development of new drugs and contributes to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic chemistry, 8-Chloro-3,4-dihydro-2H-benzo[1,4]oxazine is used as a building block for the synthesis of a variety of organic compounds. Its presence in the molecular structure can influence the reactivity and properties of the final products, making it a valuable component in the creation of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 939759-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,9,7,5 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 939759-05:
(8*9)+(7*3)+(6*9)+(5*7)+(4*5)+(3*9)+(2*0)+(1*5)=234
234 % 10 = 4
So 939759-05-4 is a valid CAS Registry Number.
939759-05-4Relevant articles and documents
Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays
Dang, Huong,Feichtinger, Konrad,Frazer, John,Grottick, Andrew J.,Kasem, Michelle,Le, Minh,Lehman, Juerg,Morgan, Michael E.,Ren, Albert,Sage, Carleton R.,Schrader, Thomas O.,Semple, Graeme,Unett, David J.,Whelan, Kevin T.,Wong, Amy,Zhu, Xiuwen
, (2020)
A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identification process, leading us to focus on a 6,5,7-tricyclic scaffold. A subsequent early SAR investigation provided potent agonists of the 5-HT2C receptor that were highly selective in both functional and binding assays, had good rat PK properties and that significantly reduced acute food intake in the rat.
