939799-57-2Relevant academic research and scientific papers
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2′-phosphono-3′-phenylcyclopropyl)glycine, the first class of 3′-substituted transC1′-2′-2-(2′-phosphonocyclopropyl)glyc ines
Marinozzi, Maura,Serpi, Michaela,Amori, Laura,Gavilan Diaz, Monica,Costantino, Gabriele,Meyer, Udo,Flor, Peter J.,Gasparini, Fabrizio,Heckendorn, Roland,Kuhn, Rainer,Giorgi, Gianluca,Hermit, Mette Brunsgaard,Thomsen, Christian,Pellicciari, Roberto
, p. 3161 - 3170 (2008/02/07)
Four stereoisomers of (2S)-2-(2′-phosphono-3′-phenylcyclopropyl)glycine were synthesized by a stereocontrolled synthetic procedure and evaluated as mGluRs ligands. The (2S,1′R,2′S,3′R)-isomer (PPCG-2) showed to be a group III mGluRs selective ligand endow
