93986-07-3

Upstream product

• 93634-55-0 2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one 
• 95-54-5 1,2-diamino-benzene 
• 104-88-1 4-chlorobenzaldehyde 
• 3617-01-4 β-(4-chlorophenyl)pyruvic acid 
• 15601-44-2 (Z/E)-4-(4-chlorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one 

Downstream Products

• 881922-66-3 2-chloro-3-(4-chloro-benzyl)-quinoxaline 
• 904673-85-4 2-chloro-3-(4-chlorobenzoyl)quinoxaline 
• 904673-83-2 3-(4-chlorobenzoyl)-quinoxalin-2(1H)-one 

Relevant academic research and scientific papers

Activated carbon/Br?nsted acid-promoted aerobic benzylic oxidation under “on-water” condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors

Green chemistry is becoming the favored approach to preparing drug molecules in pharmaceutical industry. Herein, we developed a clean and efficient method to synthesize 3-benzoylquinoxalines via activated carbon promoted aerobic benzylic oxidation under “on-water” condition. Moreover, biological studies with this class of compounds reveal an antiproliferative profile. Further structure modifications are performed and the investigations exhibited that the most active 12a could inhibit the microtubule polymerization by binding to tubulin and thus induce multipolar mitosis, G2/M phase arrest, and apoptosis of cancer cells. In addition, molecular docking studies allow the rationalization of the pharmacodynamic properties observed. Our systematic studies provide not only guidance for applications of O2/AC/H2O system, but also a new scaffold targeting tubulin for antitumor agent discovery.

Microwave-assisted solvent-dependent reaction: Chemoselective synthesis of quinoxalin-2(1 H)-ones, benzo[ d]imidazoles and dipeptides

A microwave-assisted solvent-dependent chemoselective reaction dealing with 4-arylidene-2-phenyloxazol-5-ones and diverse ortho-diamines to achieve three types of molecular scaffolds, 3-benzylquinoxalin-2(1H)-ones, benzimidazole and β-amino dipeptides is

Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

A series of new benzoylquinoxaline derivatives (7-26) was synthesized and evaluated for antitumor activity against a panel of 60 human cell lines at the NCI of Bethesda. Among the compounds which have passed the preliminary screening, compound 23 exhibite

Condensation of o-Phenylenediamines with Azlactones

Condensation of o-phenylenediamines (I) with 4-arylidene-2-substituted-oxazolin-5-ones (II) (azlactones) in acetic acid results in the formation of 3-benzyl-2(1H)quinoxalinones (III) and substituted benzimidazoles (IV).Structures of these compounds have been established based on their spectral data, and direct comparison with authentic samples prepared by unambiguous routes.