93987-17-8Relevant academic research and scientific papers
Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors
Farag, Doaa Boshra,Farag, Nahla A.,Esmat, Ahmed,Abuelezz, Sally A.,Abdel-Salam Ibrahim, Eman,Abou El Ella, Dalal A.
, p. 283 - 299 (2015)
Four novel series of 1-substituted-3-(2-methyl-4-oxo-4H-quinazolin-3-yl) urea and/or thiourea IIIa-c, 4-substituted-N-(2-methyl-4-oxo-4H-quinazolin-3-yl) benzene sulfonamide VIa-c and their NO-hybrid molecules as nitrate esters Va-c and VIIIa-c have been
Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
Liu, Ji-Feng,Lee, Jaekyoo,Dalton, Audra M.,Bi, Grace,Yu, Libing,Baldino, Carmen M.,McElory, Eric,Brown, Matt
, p. 1241 - 1244 (2007/10/03)
A practical synthesis of 2,3-disubstituted 3H-quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles.
Newer Quinazolinone Derivatives as Anthelmintic Agents
Gupta, D. P.,Ahmad, S.,Kumar, Ashok,Shanker, K.
, p. 1060 - 1062 (2007/10/02)
Five types of quinazolinone derivatives have been synthesized. 3-Amino-2-methyl-4(3H)-quinazolinones (I) on treatment with chloroacetyl chloride give the 3-chloroacetamido derivatives (II) which react with secondary and primary amines to afford the corresponding 3-substituted acetamido derivatives (III and IV).The 3-amino-quinazolinones (I) also react with aryl and alkyl halides to afford the corresponding 3-aryl/alkyl-amino derivatives (V-VII).These compounds (III-VII) have been tested for their acetylcholinesterase inhibitory activity and anthelmintic activity against H. nana.
