93989-47-0

Basic information

• Product Name: 5-(4-chlorobenzylidene)-2-(phenylimino)-1,3-thiazolidin-4-one
• Synonyms: 5-(4-chlorobenzylidene)-2-(phenylimino)-1,3-thiazolidin-4-one
• CAS NO: 93989-47-0
• Molecular Formula: C₁₆H₁₁ClN₂OS
• Molecular Weight: 314.78934
• Mol File: 93989-47-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-chlorobenzylidene)-2-(phenylimino)-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorobenzylidene)-2-(phenylimino)-1,3-thiazolidin-4-one(93989-47-0)
• EPA Substance Registry System: 5-(4-chlorobenzylidene)-2-(phenylimino)-1,3-thiazolidin-4-one(93989-47-0)

Safety Data

• Hazardous Substances Data: 93989-47-0(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 103-85-5 monophenylthiourea 
• 104-88-1 4-chlorobenzaldehyde 
• 17823-27-7 2-(phenylimino)thiazolidin-4-one 

Downstream Products

• 98131-46-5 2-anilino-2-benzyl-5-[1-(4-chloro-phenyl)-2-phenyl-ethyl]-thiazolidin-4-one 
• 96175-21-2 2-anilino-5-(4-chloro-benzhydryl)-2-phenyl-thiazolidin-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors

In this work, iminothiazolidin-4-one derivatives were explored as selective GSK-3β inhibitors. Molecular docking analysis was carried to design a series of compounds, which were synthesized using substituted thiourea, 2-bromoacetophenones and benzaldehydes. Out of the twenty five compounds synthesized during this work, the in?vitro evaluation against GSK-3 led to the identification of nine compounds with activity in lower nano-molar range (2–85?nM). Further, in?vitro evaluation against CDK-2 showed five compounds to be selective towards GSK-3.