940-54-5

Usage

Uses

Used in Pharmaceutical Industry:
(1E)-1-butylidene-2-phenylhydrazine is used as an intermediate in the production of pharmaceuticals for its potential use in the treatment of various diseases and medical conditions. Its anti-inflammatory, antioxidant, and anti-tumor properties make it a promising candidate for developing new drugs.
Used in Agrochemical Industry:
(1E)-1-butylidene-2-phenylhydrazine is used in the production of agrochemicals, where it has been studied for its potential as a pesticide. Its insecticidal and fungicidal properties make it a valuable component in developing effective and environmentally friendly pest control solutions.
Used in Research and Development:
(1E)-1-butylidene-2-phenylhydrazine is used as a research compound for studying its various biological activities and potential applications in medicine and agriculture. Its versatility and range of properties make it an important compound for scientific investigation and innovation.

Upstream product

• 540-63-6 ethane-1,2-dithiol 
• 123-72-8 butyraldehyde 
• 100-63-0 phenylhydrazine 
• 99167-08-5 N-butyl-N'-phenylhydrazine 

Downstream Products

• 1484-19-1 3-ethyl-1H-indole 
• 74830-05-0 4-phenyl-5-phenylimino-2-propyl-1,3,4-thiadiazolidine 
• 123-72-8 butyraldehyde 
• 957188-41-9 1-phenyl-3-propyl-5-trifluoromethyl-1H-pyrazole 
• 83637-23-4 2-sec-butyl-cyclohexylamine 
• 4632-01-3 2-sec.-butylcyclohexanol 
• 127680-03-9 ((Z)-But-1-enyl)-phenyl-diazene 
• 74327-71-2 but-1-enyl-phenyl-diazene 
• 81323-29-7 N-Phenyl-N'-1-aminobutylhydrazine 
• 861598-53-0 (E)-2-butylidene-1,1-diphenylhydrazine 
• 111-92-2 dibutylamine 
• 109-73-9 N-butylamine 
• 62-53-3 aniline 
• 115591-30-5 5-Methyl-1-phenyl-3-propyl-1H-[1,2,4]triazole 

Relevant academic research and scientific papers

Dehydrogenation of 1-(diphenylphosphinoyl)-2-(N′-phenylhydrazino) ethane and N-butyl-N′-phenylhydrazine

Dehydrogenation of 1-(diphenylphosphinoyl)-2-hydrazino-substituted ethanes and N-butyl-N′-phenylhydrazine to the corresponding hydrazone derivatives is performed. Both reactions were established to involve predominantly, if not exclusively, an azo interme

Nano BF3·SiO2: A green heterogeneous solid acid for synthesis of formazan dyes under solvent-free condition

A solvent-free, efficient and rapid approach for synthesis of formazan dyes was developed by diazotization of aromatic amines with NaNO2, nano silica-supported boron trifluoride (nano BF3·SiO2), then diazo coupling with aldehyde phenylhydrazones by grinding method at room temperature. This study aimed to overcome the limitations and drawbacks of the previous reported methods such as: low temperature, using corrosive and toxic acids and solvents, using buffer solutions, instability of aryl diazonium salts, modest yields, and long reaction times.

Fast hydrazone reactants: Electronic and acid/base effects strongly influence rate at biological pH

Kinetics studies with structurally varied aldehydes and ketones in aqueous buffer at pH 7.4 reveal that carbonyl compounds with neighboring acid/base groups form hydrazones at accelerated rates. Similarly, tests of a hydrazine with a neighboring carboxylic acid group show that it also reacts at an accelerated rate. Rate constants for the fastest carbonyl/hydrazine combinations are 2-20 M-1 s-1, which is faster than recent strain-promoted cycloaddition reactions.

Novel 1,5,3-dithiazepanes: Three-component synthesis, stereochemistry, and fungicidal activity

Three-component heterocyclization of hydrazine with formaldehyde and ethane-1,2-dithiol gave previously unknown 3,3′-bi(1,5,3-dithiazepane). Its stereochemistry was determined by X-ray diffraction. The reaction with higher aliphatic aldehydes RCHO (R = Me

Synthesis of 3-ethyl indole

In this study, it is planned to synthesize intermediates to get β-carboline alkaloids having effective bioligical activities. In this way, we tried to synthesize 3-ethyl indole as an intermediate from simple and cheap compounds to obtain the β-carboline s

Ytterbium(III) perfluorooctanoate catalyzed one-pot, three-component synthesis of fully substituted pyrazoles under solvent-free conditions

A convenient one-pot synthesis of fully substituted pyrazoles via three-component condensations of phenylhydrazine, aldehydes, and 1,3-dicarbonyl compounds using ytterbium perfluorooctanoate [Yb(PFO)3] as catalyst under solvent-free conditions is described. The reusable catalyst can be easily prepared and was efficient for the reaction. A possible mechanism is suggested. Georg Thieme Verlag Stuttgart.

Palladium-catalyzed synthesis of aryl ketones by coupling of aryl bromides with an acyl anion equivalent

Palladium-catalyzed couplings of aryl bromides with N-tert-butylhydrazones as acyl anion equivalents to form aryl ketones are reported. The coupling process occurs at the C-position of hydrazones to form N-tert-butyl azo compounds. Isomerization of these azo compounds to the corresponding hydrazones, followed by hydrolysis, gave the desired mixed alkyl aryl ketones. The selectivity of C- versus N-arylation was strongly influenced by the substituent on nitrogen. Arylation at carbon occurred with N-tert-butylhydrazones, whereas N-arylation occurred with N-arylhydrazones. The arylation of hydrazones containing primary and secondary alkyl groups, as well as aryl groups, gave the desired ketones in good yields after hydrolysis. Functional groups on the aromatic ring, such as alkoxy, cyano, trifluoromethyl, carboalkoxy, carbamoyl, and keto groups, were tolerated. This reaction likely occurs by C-C bond-forming reductive elimination from an intermediate containing an η1-diazaallyl ligand. Copyright

Electrochemical formation of methoxy- and cyano(phenylazo)alkanes from aldehyde and ketone phenylhydrazones

Several aldehyde and ketone phenylhydrazones were electrooxidized in MeOH. Electrooxidation in the presence of KI or tetraethylammonium p-toluenesulfonate as the supporting electrolyte afforded the corresponding methoxy(phenylazo)alkanes, whereas electrooxidation in the presence of KI, NaCN, and HOAc afforded the cyano(phenylazo)alkanes.