94026-73-0

Usage

Uses

Used in Dye and Pigment Production:
N-p-Tolyl-2,4-xylidine is used as a key component in the formulation of dyes and pigments for various applications, such as coloring textiles, plastics, and paints. Its aromatic amine structure contributes to the color properties and stability of these products.
Used in Pharmaceutical Industry:
N-p-Tolyl-2,4-xylidine is used as an intermediate in the synthesis of pharmaceutical compounds, playing a crucial role in the development of new drugs and medications. Its chemical properties allow for the creation of diverse molecular structures with potential therapeutic effects.
Used in Organic Synthesis:
As an intermediate in organic synthesis, N-p-Tolyl-2,4-xylidine is utilized in the production of various organic compounds, contributing to the development of new chemical entities with a wide range of applications, from materials science to specialty chemicals.
Used in Polymer Manufacturing:
N-p-Tolyl-2,4-xylidine is employed in the manufacturing of polymers, where it serves as a building block for the creation of polymeric materials with specific properties. Its incorporation into polymer structures can enhance characteristics such as color, stability, and performance in various applications.

Upstream product

• 2101-86-2 p-methylazidobenzene 
• 108-38-3 m-xylene 
• 540-23-8 p-toluidine hydrochloride 
• 95-68-1 2,4-Xylidine 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 106-49-0 p-toluidine 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 1609171-51-8 N-(2,4-dimethylphenyl)-N-(p-tolyl)naphthalene-1-amine 

Relevant academic research and scientific papers

Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.

Synthesis of sterically congested triarylamines by palladium-catalyzed amination

An efficient protocol for the palladium-catalyzed synthesis of sterically congested triarylamines from commercially available 1-chloro- or 1-bromonaphthalenes and diarylamines is described. The application of alkyllithium reagents as strong bases and a combination of Pd(OAc)2 and SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) plays a crucial role in the success of this otherwise difficult to achieve C-N coupling reaction. A variety of secondary aromatic amines with versatile steric and electronic properties can be successfully used in this transformation to give the desired triarylamines in up to 99 % yield. The obtained products are important structural motifs in hole-transport materials for organic light-emitting diode applications. A variety of secondary aromatic amines are coupled with 1-halonaphthalenes to give sterically highly congested triarylamines in up to 99 % yield. The key to the success of this transformation is prior deprotonation of the amine with strong bases such as n-hexyllithium. Copyright

Copper-catalyzed N-arylation of amines with hypervalent iodonium salts

The copper-catalyzed N-arylation of amines with hypervalent iodonium compounds with secondary aliphatic amines, aromatic amines, azoles and amides was accomplished with catalytic CuI (10 mol%) or Cu(acac)2 (5 mol%) in the presence of Na2CO3 or K2CO3 as a base in CH2Cl2 or toluene under mild conditions.

ALIPHATIC C-H, N-INSERTION VERSUS AROMATIC N-SUBSTITUTION IN THE REACTION OF ARYLNITRENIUM-BORON TRIFLUORIDE COMPLEXES WITH METHYLATED BENZENES

The boron trifluoride promoted decomposition of a number of substituted phenyl azides in toluene, para-xylene, meta-xylene or mesitylene at 60 gradC, leads preferentially to N-benzylamines or diarylamines depending on both ring substituent effect and nucleophilic character of the solvent.