94058-86-3

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• 64037-25-8 5-chloro-2-methylsulfanyl-benzooxazole 
• 103-67-3 benzyl-methyl-amine 
• 103-83-3 N,N'-dimethylbenzylamine 
• 17200-29-2 5-chloro-benzoxazole 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 100-46-9 benzylamine 
• 74-88-4 methyl iodide 
• 78749-89-0 N-benzyl-5-chloro-1,3-benzoxazol-2-amine 

Relevant academic research and scientific papers

nBu4NI-catalyzed direct amination of benzoxazoles with tertiary amines using TBHP as oxidant under microwave irradiation

A facile, efficient, and practical method for nBu4NI-catalyzed direct C-H amination of benzoxazoles with tertiary amines has been developed. The system could be performed in the absence of metal catalyst and only requires tert-butyl

Heterogeneously porous γ-MnO2-catalyzed direct oxidative amination of benzoxazole through C-H activation in the presence of O2

Oxidative amination of azoles through catalytic C-H bond activation is a very important reaction due to the presence of 2-aminoazoles in several biologically active compounds. However, most of the reported methods are performed under homogeneous reaction conditions using excess reagents and additives. Herein, we report the heterogeneous, porous γ-MnO 2-catalyzed direct amination of benzoxazole with wide range of primary and secondary amines. The amination was carried under mild reaction conditions and using molecular oxygen as a green oxidant, without any additives. The catalyst can easily be separated by filtration and reused several times without a significant loss of its catalytic performance. Of note, the reaction tolerates a functional group such as alcohol, thus indicating the broad applicability of this reaction.

Copper-catalyzed direct oxidative C-H amination of benzoxazoles with formamides or secondary amines under mild conditions

A facile, efficient, and practical method for copper-catalyzed direct C-H amination of benzoxazoles with formamides or secondary amines has been developed. The system can be performed in the absence of external base and only requires O2 or even air as oxidant. A variety of substituted benzoxazol-2-amines were synthesized with moderate to excellent yield.

A New Method for the Preparation of 2-(Alkylamino)benzoxazoles and 2-(Alkylimino)benzoxazolines

New syntheses of 2-(alkylamino)benzoxazoles (III) and 3-alkyl-2-(alkylimino)benzoxazolines (IV) were developed.Various compounds III were obtained by the reaction of 2-(methylthio)benzoxazole with amines.In the alkylation of 2-(monoalkylamino)benzoxazoles, the use of a base as a catalyst was found to be important for the selective preparation of 2-(N,N-dialkylamino)benzoxazoles; in the absence of base, IV was obtained.On the other hand, alkylation of N,N'-dialkyl-N-(2-hydroxyphenyl)thioureas resulted in the development of another method for the preparation of IV.Keywords - 2-(alkylamino)benzoxazole; 3-alkyl-2-(alkylimino)benzoxazoline; 2-(methylthio)benzoxazole; N,N'-dialkyl-N-(2-hydroxyphenyl)thiourea; 3-alkylbenzoxazoline-2-thione