64037-25-8

Basic information

• Product Name: 5-Chloro-2-(methylthio)benzoxazole
• Synonyms: 5-Chloro-2-(methylthio)benzoxazole
• CAS NO: 64037-25-8
• Molecular Formula: C₈H₆ClNOS
• Molecular Weight: 199.66
• Mol File: 64037-25-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 87-89 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 310.4°Cat760mmHg
• Flash Point: 141.5°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.661
• PKA: -0.66±0.10(Predicted)
• CAS DataBase Reference: 5-Chloro-2-(methylthio)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-(methylthio)benzoxazole(64037-25-8)
• EPA Substance Registry System: 5-Chloro-2-(methylthio)benzoxazole(64037-25-8)

Safety Data

• Hazardous Substances Data: 64037-25-8(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-(methylthio)benzoxazole, also known as NSC 18321, is a chemical compound with the molecular formula C8H6ClNOS. It is a benzoxazole derivative that contains a chlorine atom and a methylthio group. 5-Chloro-2-(methylthio)benzoxazole is used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. It has also been studied for its potential antitumor and antiviral activities. 5-Chloro-2-(methylthio)benzoxazole is a yellow, crystalline solid that is stable under normal conditions. It is important to handle this compound with care due to its potential hazards and to follow proper safety protocols when working with it.

InChI:InChI=1/C8H6ClNOS/c1-12-8-10-6-4-5(9)2-3-7(6)11-8/h2-4H,1H3

Upstream product

• 22876-19-3 5-chloro-2-mercaptobenzoxazole 
• 74-88-4 methyl iodide 
• 22876-19-3 5-chlorobenzo[d]oxazole-2(3H)-thione 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1049799-47-4 5-chloro-2-(4-chloroanilino)-1,3-benzoxazole 
• 94058-92-1 Benzyl-[5-chloro-3-phenethyl-3H-benzooxazol-(2E)-ylidene]-amine 
• 94058-89-6 2-(N-benzyl-N-phenetylamino)-5-chlorobenzoxazole 
• 94058-91-0 Benzyl-[3-benzyl-5-chloro-3H-benzooxazol-(2E)-ylidene]-amine 
• 94058-87-4 N,N-dibenzyl-5-chlorobenzo[d]oxazol-2-amine 
• 94058-88-5 2-(N-benzyl-N-phenylamino)-5-chlorobenzoxazole 
• 94058-90-9 Benzyl-[5-chloro-3-methyl-3H-benzooxazol-(2E)-ylidene]-amine 
• 94058-86-3 N-benzyl-5-chloro-N-methylbenzo[d]oxazol-2-amine 
• 78749-89-0 N-benzyl-5-chloro-1,3-benzoxazol-2-amine 
• 79558-94-4 5-chloro-N-phenyl-1,3-benzoxazole-2-amine 
• 78750-03-5 5-chloro-2-(piperidin-1-yl)benzoxazole 

Relevant articles and documents

EHPATITIS B ANTIVIRAL AGENTS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-Z-L-R1 (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

An easy and fast ultrasonic selective S-alkylation of hetaryl thiols at room temperature

A series of 2-alkylthio derivatives of hetaryl thiols were synthesized by selective S-alkylation with alkyl halides (bromides and iodides) with ultrasonic irradiation at room temperature. The reaction was found to be generally applicable to hetaryl thiol derivatives with different substituents in the aromatic nucleus and various alkyl halides. The reaction gives high to excellent yields of products with high purity.

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.