94059-41-3Relevant academic research and scientific papers
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation
Zhang, Shao-Lin,Hu, Xiaohui,Zhang, Wen,Tam, Kin Yip
supporting information, p. 3562 - 3568 (2016/05/19)
Pyruvate dehydrogenase kinases (PDKs) have recently emerged as an attractive target for cancer therapy. Herein, we prepared a series of compounds derived from dichloroacetate (DCA) which inhibited cancer cells proliferation. For the first time, we have successfully developed DCA derived inhibitors that preferentially bind to the adenosine triphosphate (ATP) pocket of PDK isoform 1 (PDK1).
Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof
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, (2008/06/13)
Novel compounds having the structural formula STR1 wherein R1 and R2 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, alkoxy, cyano and nitro are provided. The compou
