941282-79-7Relevant academic research and scientific papers
Enantioselective synthesis of hydrobenzofuranones using an asymmetric desymmetrizing intramolecular stetter reaction of cyclohexadienones
Liu, Qin,Rovis, Tomislav
supporting information, p. 598 - 604 (2012/12/31)
A series of cyclohexadienones were synthesized by dearomatization of phenols followed by Dess - Martin oxidation. Asymmetric intramolecular Stetter reactions of these substrates provide hydrobenzofuranones in good to excellent yields and excellent stereoselectivities. Up to three stereocenters as well as a quaternary stereocenter are formed from polysubstituted substrates. A scale-up experiment demonstrates the utility of this transformation.
Asymmetric synthesis of hydrobenzofuranones via desymmetrization of cyclohexadienones using the intramolecular Stetter reaction
Liu, Qin,Rovis, Tomislav
, p. 2552 - 2553 (2007/10/03)
Dearomatization of phenols followed by oxidation affords cyclohexadienyloxyacetaldehydes, which produce hydrobenzofuranones via asymmetric intramolecular Stetter reaction in good to excellent yield. Quaternary as well as up to three contiguous stereocenters may be formed in good to excellent enantioselectivities and high diastereoselectivities. Copyright
