94166-57-1

Usage

InChI:InChI=1/C8H11N3O3/c1-3-9-8-6(11(12)13)4-5-7(10-8)14-2/h4-5H,3H2,1-2H3,(H,9,10)

Upstream product

• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 75-04-7 ethylamine 

Relevant academic research and scientific papers

Imidazo [4, 5-b] pyridine compounds with biological activity as well as preparation method and application of imidazo [4, 5-b] pyridine compounds

The invention discloses imidazo [4, 5-b] pyridine compounds with biological activity as well as a preparation method and application of the imidazo [4, 5-b] pyridine compounds. The structure of the the imidazo [4, 5-b] pyridine compounds is as shown in a general formula (I), wherein R represents a hydrogen or halogen atom; R1 represents hydrogen or a methyl group; R2 represents hydrogen, a C1-C4 linear or branched alkyl group, or a heterocyclic benzyl group, the heterocyclic ring is a five-membered aromatic heterocyclic ring, and the hydrogen atom on a heterocyclic ring is unsubstituted, optionally substituted by the C1-C4 linear or branched alkyl group, or optionally substituted by the halogen atom; Ar represents a phenyl group, a thienyl group or a thiazolyl group, wherein a hydrogen atom on the ring is unsubstituted, or optionally substituted by a substituent independently selected from a halogen atom, a methoxy group, a methyl group and a halogenated methyl group; X represents O, S, SO or SO2. The compounds shown in the formula (I) have the bactericidal, insecticidal/acaricidal broad-spectrum activity at an amount of 15-5000g of active ingredient per hectare.

Design, Synthesis, and Fungicidal Activity of Novel Imidazo[4,5-b]pyridine Derivatives

A series of novel imidazo[4,5-b]pyridine derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by spectroscopic data NMR, MS, and elemental analysis. Bioassay showed that the compounds exhibited potent fungicidal activities against Erysiphe graminis, Puccinia polysora, and so forth. Particularly, 2-chloro-5-((5-methoxy-2-(2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)thiazole (9b) displayed fungicidal potency against P.?polysora. Its EC50 value: 4.00?mg/L is comparable with that of tebuconazole. The structure–activity relationship for the target compounds is discussed.