941716-91-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrrolidin-1-YL-1,3-THIAZOLE-5-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with diverse therapeutic properties.
Used in Medicinal Chemistry Research:
2-Pyrrolidin-1-YL-1,3-THIAZOLE-5-CARBOXYLIC ACID is used as a target compound in medicinal chemistry research to explore its biological activity and evaluate its potential as a precursor for creating effective therapeutic agents.
Used in Organic Chemistry:
2-Pyrrolidin-1-YL-1,3-THIAZOLE-5-CARBOXYLIC ACID is used as a versatile building block in organic chemistry for its ability to form a variety of complex molecular structures, facilitating advancements in chemical synthesis and compound design.

Upstream product

• 123-75-1 pyrrolidine 
• 54045-76-0 2-bromo-thiazole-5-carboxylic acid 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

4-PYRIDONE COMPOUND OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION AND FORMULATION INCLUDING SAME

An object of the present invention is to provide a compound or a salt thereof having anti-HBV activity, a pharmaceutical composition, an anti-hepatitis B virus agent, a production inhibitor of DNA of a hepatitis B virus, and a production or secretion inhibitor of a hepatitis B surface antigen. According to the present invention, provided are a compound represented by General Formula [1] or a salt thereof: (in the formula, R1 represents a benzothiazolyl group which may be substituted (in which a carbon atom constituting the 6-membered ring of the benzothiazolyl group of R1 is bonded to the nitrogen atom of the pyridone ring); R2 represents a C2-6 alkenyl group which may be substituted, or the like; and R3 represents a hydrogen atom or the like).