94201-73-7Relevant academic research and scientific papers
Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions
Chen, Tiantian,Dong, Guangbin,Xing, Dong,Yang, Haijian,Yang, Yang
, p. 4238 - 4243 (2020/05/05)
We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.
gamma-alkenyl ketone and preparation method thereof
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Paragraph 0227-0231, (2020/02/29)
The invention discloses a gamma-alkenyl ketone preparation method, wherein the target product can be obtained at high yield and high regioselectivity by using acetophenone and 1,3-butadiene as raw materials in the presence of an organic solvent, a catalyst, an additive and a ligand. According to the invention, the method has advantages of high atom economy, high regioselectivity, high yield and the like, can achieve the efficient conversion from a cheap basic organic chemical product 1,3-butadiene to high-added-value gamma-alkenyl ketone, and uses the cheap catalyst, so that the reaction conditions are neutral and mild, and the experimental operation is safe and simple; and the synthesized gamma-alkenyl ketone is a useful synthetic intermediate, can be subjected to a series of conversionsto obtain a series of drug molecule precursors or key intermediates, and has wide application prospect.
Cyclization of Alkoxymethyl Radicals
Rawal, Viresh H.,Singh, Surendra P.,Dufour, Claire,Michoud, Christophe
, p. 5245 - 5247 (2007/10/02)
Alkoxymethyl radicals, generated conveniently from phenylseleno precursors, cyclize to afford substituted tetrahydrofurans and tetrahydropyrans in excellent yield and with good stereoselectivity.
