94209-49-1

Upstream product

• 96999-05-2 methyl N-(2-carbomethoxyphenyl)propionimidate 
• 2916-09-8 2-ethyl-benzo[d][1,3]oxazin-4-one 
• 134-20-3 2-carbomethoxyaniline 
• 460062-44-6 2-(2-propionylamino-benzoylamino)-benzoic acid methyl ester 
• 31499-90-8 2,1-benzisoxazol-3(1H)-one 

Downstream Products

• 1026949-89-2 2-[2-(1-amino-ethyl)-4-oxo-4H-quinazolin-3-yl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Oxygen analogues of the benzodiazepine alkaloids sclerotigenin and circumdatin F

A new type of fused oxazepinones 9a and 9b, which are analogues of sclerotigenin and circumdatin F, were obtained in a two step synthesis from 2-(2-amino-benzoylamino)-benzoic acid or the corresponding methyl ester. Secondly a new synthesis of circumdatin F arose from this work, where 2-(2-propionylaminobenzoylamino)-benzoic acid methyl ester was used as an intermediate.

Synthesis of 3-Amino-4-(3H)-quinazolinones from N-(2-Carbomethoxyphenyl) Imidate Esters

Novel difunctional aromatic synthons consisting of N-(2-carbomethoxyphenyl) imidate esters were synthesized by treatment of methyl anthranilate esters with aliphatic ortho esters.Treatment of the imidates with hydrazine, methylhydrazine, and phenylhydrazine yielded only quinazolinones and not isomeric 1,3,4-benzotriazepin-5-ones.The type of products obtained gave information relevant to elucidation of the mechanism of cyclization and the relative reactivities of the ester and imidate groups.