942220-63-5

Basic information

• Product Name: 1-tert-butyl-5-methyl (2S,3S,1'R,αS)-2-[1'-phenyl-1'-(N-benzyl-N-α-methylbenzylamino)methyl]-3-phenylpentanedioate
• Synonyms: 1-tert-butyl-5-methyl (2S,3S,1'R,αS)-2-[1'-phenyl-1'-(N-benzyl-N-α-methylbenzylamino)methyl]-3-phenylpentanedioate
• CAS NO: 942220-63-5
• Molecular Weight: 577.764
• Mol File: 942220-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-tert-butyl-5-methyl (2S,3S,1'R,αS)-2-[1'-phenyl-1'-(N-benzyl-N-α-methylbenzylamino)methyl]-3-phenylpentanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl-5-methyl (2S,3S,1'R,αS)-2-[1'-phenyl-1'-(N-benzyl-N-α-methylbenzylamino)methyl]-3-phenylpentanedioate(942220-63-5)
• EPA Substance Registry System: 1-tert-butyl-5-methyl (2S,3S,1'R,αS)-2-[1'-phenyl-1'-(N-benzyl-N-α-methylbenzylamino)methyl]-3-phenylpentanedioate(942220-63-5)

Safety Data

• Hazardous Substances Data: 942220-63-5(Hazardous Substances Data)

Upstream product

• 133812-18-7 (S)-4-benzyl-3-(6-(benzyloxy)hex-2-enoyl)oxazolidin-2-one 
• 265669-72-5 tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate 
• 103-26-4 methyl cinnamate 
• 67-56-1 methanol 

Relevant articles and documents

Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinones

The efficiency and stereoselectivity of the conjugate addition of lithium (Z)- or (E)-β-amino ester enolates, generated by lithium amide conjugate addition to an α,β-unsaturated ester or deprotonation of a β-amino ester, respectively, to a range of α,β-unsaturated acceptors has been investigated. Deprotonation of a β-amino ester with LDA, followed by conjugate addition to a chiral α,β-unsaturated oxazolidinone gives high 2,3-anti selectivity (～90% d.e.), with hydrogenolysis and purification to homogeneity generating stereodefined trisubstituted piperidinones as single stereoisomers. Asymmetric three-component couplings of α,β-unsaturated esters and alkylidene malonates initiated by lithium amide conjugate addition proceeds with high levels of 2,3-anti stereoselectivity, with hydrogenolysis giving tetrasubstituted piperidinones. This journal is The Royal Society of Chemistry.